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Pathogens
Special Issues
Pathogenesis, Diagnosis, and Innovative Therapies in Clinical Infections
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Pathogenesis, Diagnosis, and Innovative Therapies in Clinical Infections

A special issue of Pathogens (ISSN 2076-0817).

Deadline for manuscript submissions: 10 February 2026 | Viewed by 257

Special Issue Editors

Dr. Anna Gidari

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Guest Editor
1. Clinic of Infectious Diseases, University of Perugia, Perugia, Italy
2. Clinic of Infectious Diseases, Azienda Ospedaliera Santa Maria di Terni, Terni, Italy
Interests: antibiotics; antibiotic resistance; antimicrobial stewardship; clinical virology; virology; infectious diseases; SARS-CoV-2
Dr. Elisabete Machado

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Guest Editor
1. UCIBIO-REQUIMTE—Applied Molecular Biosciences Research Unit, Laboratory of Microbiology, Faculty of Pharmacy, University of Porto, 4099-002 Porto, Portugal
2. RISE-Health, Faculty of Health Sciences, Fernando Pessoa University, Fernando Pessoa Teaching and Culture Foundation, 4200-150 Porto, Portugal
Interests: antimicrobial resistance and infectious diseases; enterobacterales; β-Lactamases; epidemiology of antimicrobial resistance (clones, mobile genetic elements, healthcare institutions, community); role of non-hospital ecological niches in the selection and dissemination of clinically relevant antibiotic resistance genes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Clinical infection refers to various infectious diseases caused by pathogens (bacteria, viruses, fungi, parasites) and presenting with noticeable signs and/or symptoms. These diseases pose a significant threat to global health due to the diversity of pathogens and the challenges in treating them. This Special Issue highlights cutting-edge research findings on pathogen–host interactions, rapid diagnostic technologies and novel drugs and other therapeutic strategies.

Topics of interest include, but are not limited to, the following research areas:

  • Host–pathogen interaction: Studying the interaction between pathogens and the host immune system and its role in disease progression and severity.
  • Rapid diagnostic technologies: Using molecular biology methods such as PCR, next-generation sequencing technologies and biomarker-based strategies for rapid and accurate identification of pathogens.
  • Antibiotic resistance research: Analyzing the evolutionary mechanisms of pathogen resistance and exploring new antibiotics and alternative treatment strategies to address the problem of multidrug resistance.
  • Novel therapeutic strategies: Exploring innovative treatments for clinical infections, including vaccine development and immunotherapy research.

We welcome original research papers, comprehensive reviews and case reports that showcase the latest developments in this field. We look forward to your valuable contributions and to working together to advance the field of clinical infection.

Dr. Anna Gidari
Dr. Elisabete Machado
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • clinical infections
  • infectious diseases
  • pathogenesis
  • diagnosis
  • therapies
  • antibiotic resistance

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Published Papers (1 paper)

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Research

12 pages, 547 KB  
Article
Exploratory Study on Efficacy and Safety of Minocycline-Based Dual Therapy for Helicobacter pylori Eradication
by Wen Gao, Jingwen Li, Yuling Tian, Chaoyi Ge, Chi Wang, Jianxiang Liu, Yixuan Li and Hong Cheng
Pathogens 2025, 14(11), 1121; https://doi.org/10.3390/pathogens14111121 - 3 Nov 2025
Abstract
Background & Aims: This study aimed to evaluate the feasibility of vonoprazan–minocycline (VM) dual therapy for Helicobacter pylori infection. Methods: In this open-label RCT, 120 H. pylori-infected patients (60 treatment-naïve and 60 treatment-failure cases) were randomized to receive vonoprazan–amoxicillin dual therapy (VA: [...] Read more.
Background & Aims: This study aimed to evaluate the feasibility of vonoprazan–minocycline (VM) dual therapy for Helicobacter pylori infection. Methods: In this open-label RCT, 120 H. pylori-infected patients (60 treatment-naïve and 60 treatment-failure cases) were randomized to receive vonoprazan–amoxicillin dual therapy (VA: vonoprazan 20 mg b.i.d. + amoxicillin 1.0 g t.i.d., control group) or VM dual therapy (vonoprazan 20 mg b.i.d. + minocycline 100 mg b.i.d., test group) for 14 days. The primary outcome was eradication rates. Secondary outcomes included adverse effects (AEs). Results: As first-line treatment, eradication rates were 96.7% (VA) vs. 90.0% (VM) in intention-to-treat (ITT) analysis (p = 0.30) and 96.7% (VA) vs. 96.4% (VM) in per-protocol (PP) analysis (p = 0.96). For rescue treatment, eradication rates were 86.7% (VA) vs. 76.7% (VM) in ITT (p = 0.32) and 89.7% (VA) vs. 79.3% (VM) in PP (p = 0.28). Overall eradication rates were 91.7% (VA) vs. 83.3% (VM) in ITT (p = 0.17) and 93.2% (VA) vs. 87.7% (VM) in PP (p = 0.31). VM had a higher incidence of AEs than VA (30.0% vs. 10.0%, p = 0.006), with dizziness being the most common (18.3%). Conclusions: VM dual therapy was shown to be an effective and safe treatment option, demonstrating comparable eradication rates to VA dual therapy. While VM had a slightly higher incidence of AEs, they were generally mild and manageable. VM remained a valuable alternative for patients with penicillin allergies or amoxicillin resistance. Full article
(This article belongs to the Special Issue Pathogenesis, Diagnosis, and Innovative Therapies in Clinical Infections)
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