Viruses and the Nervous System in the 21st Century: Advances and Challenges
A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Viral Pathogens".
Deadline for manuscript submissions: closed (15 November 2023) | Viewed by 1566
Special Issue Editor
Interests: innate immune signaling; microglia; astrocytes; macrophages; RNA virus; inflammation; organ-on-a-chip; mouse model
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
More than 3,000 years ago an Egyptian stele depicted the severe consequences of a virus infection of the nervous system, now identified as polio. Among emerging viruses, at least 50% are associated with severe neurological clinical symptoms. The COVID-19 pandemic highlights the association between respiratory viruses and neurological symptoms, and moreover, our poor understanding on how peripheral responses to virus infections affect central nervous system (CNS) function. Viruses can affect the function of the nervous system directly through infection or by indirect mechanisms, inducing a broad range of acute and long-term sequelae. The recent, remarkable discovery of the brain’s glymphatic system has reshaped our understanding of the CNS, challenging the concept of its “immune privilege” nature. Moving forward, the prevention and effective treatment of viral infections and their associated neurological disorders is complex, and requires the crosstalk between diverse disciplines including neurovirology, neuroimmunology, neuroscience, ecology, epidemiology, and emerging “omics” approaches.
In this Special Issue of Pathogens, we invite both original research articles and reviews that provide novel insights into the molecular biology, epidemiology, and pathogenesis of neurotropic and opportunistic viral infections of the nervous system. Potential topics include, but are not limited to:
- acute and persistent virus infections of the CNS
- impact of virus inflammation in the periphery in the CNS
- therapeutic strategies: antivirals and neuroimmune modulators
- viruses associated with autoimmune disorders affecting the CNS
- SARS-CoV-2 neurologic complications
- epidemiology of neurotropic virus infections
- virus-induced neurobehavioral studies
- organoids and organs-on-a-chip to model neurotropic viral infections
- neuro-omics
We look forward to your contribution.
Dr. Sonia Navas-Martin
Guest Editor
Manuscript Submission Information
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Keywords
- neurovirology
- neuroinmmunology
- neuro-omics
- organoids
- organ-on-a-chip
- mouse model
