Host Interaction and Immune Modulation of RNA Viruses

Dear Colleagues,

Continued global public health threats posed by RNA viruses underscore the critical need for a deeper understanding of their pathogenic processes and the urgent development of targeted therapeutic strategies. The intrusion of these viruses into host cells initiates a cascade of immune responses, primarily activating the innate immune system. During viral replication, pathogen-associated molecular patterns are released, which are then recognized by the host's pattern-recognition receptors, thereby initiating innate immune responses. As an integral part of the initial antiviral defense, the innate immune system is pivotal in recognizing pathogens and launching robust antiviral responses, which not only help to curtail viral replication and dissemination but also stimulate the adaptive immune response.

In this Special Issue, we focus on elucidating the primary mechanisms employed by emerging and re-emerging RNA viruses to circumvent the innate immune system, with a particular emphasis on pathogens posing substantial risks to public health. This Special Issue aims to offer an overview of the latest research on RNA virus-mediated infections, collating significant advancements in the regulation of the innate immune response against viruses and in the development of antiviral strategies that target the innate immune system. We encourage the submission of original research articles, review papers, case reports, communications, and study protocols within the scope of host interactions and immune modulations of RNA viruses.

Dr. Zhenlong Liu
Prof. Dr. Sonia Navas-Martin
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• RNA viruses
• viral immunology
• antiviral therapy development