Exploring Natural Products as Antiparasitic Agents: Efficacy Against Parasites of Veterinary and Public Health Significance

A special issue of Parasitologia (ISSN 2673-6772).

Deadline for manuscript submissions: 31 January 2026 | Viewed by 401

Special Issue Editors


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Guest Editor
Laboratory of Helminthology, National Centre for Disciplinary Research in Animal Health and Innocuity (CENID-SAI), National Institute for Research in Forestry, Agriculture and Livestock, INIFAP-SADER, Jiutepec 62550, Mexico
Interests: plant extracts; phenolic acids; gastointetinal nematodes; natural products
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Tropical Livestock Center, Faculty of Veterinary Medicine and Zootechnics, National Autonomous University of Mexico (CEIEGT-FMVZ-UNAM), Martínez de la Torre, Veracruz 93600, Mexico
Interests: plant extract; secondary metabolites; phytochemicals; nematodes; biological control
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

The increasing prevalence of anthelmintic resistance among the three major groups of parasites (helminths, protozoa, and arthropods) affecting domesticated animals (pets and livestock) represents a significant challenge to both public and veterinary health. Thus, the development of novel antiparasitic agents is crucial. In this context, natural products derived from plants, fungi, and marine organisms have emerged as a promising resource. 

We are excited to invite you to submit your work for the upcoming Special Issue called “Exploring Natural Products as Antiparasitic Agents: Efficacy Against Parasites of Veterinary and Public Health Significance” and thereby contribute to this topic with original research articles, reviews, and short communications. This Special Issue aims to showcase the latest advancements in the development of novel antiparasitic agents, thereby allowing access to up-to-date knowledge on the subject and guiding future research in this field.

The topics of interest include (but are not limited to) the following:

  • The Discovery of Novel Natural Products as Parasiticide Agents;
  • Advancements in Formulating Natural Compounds for Effective Endo- and Ectoparasite Management;
  • Explorations of the Potential Mechanisms of Action of Natural Compounds;
  • Structural and Functional Analyses of Secondary Metabolites Targeting Parasitic Organisms.

We look forward to receiving your valuable contributions!

You may choose our Joint Special Issue in Pathogens.

Dr. Agustín Olmedo-Juárez
Dr. Elke Von Son-De Fernex
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Parasitologia is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • plant extracts
  • phytochemicals
  • fungi
  • parasites
  • anthelmintics
  • secondary metabolites
  • natural compounds
  • ethnoveterinary

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Published Papers (1 paper)

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Research

17 pages, 2370 KiB  
Article
Infective Larvae of Haemonchus contortus (Nematoda: Trichostrongylidae) Are Captured and Destroyed by Nematode-Trapping Fungi Dactylellina spp. (Fungi: Orbiliales)
by Manuel Salvador Balanzar-Aguilera, Enrique Gutiérrez-Medina, Gustavo Pérez-Anzúrez, Edgar Jesús Delgado-Núñez, María Eugenia López-Arellano, Ana Yuridia Ocampo-Gutiérrez and Pedro Mendoza-de Gives
Parasitologia 2025, 5(2), 26; https://doi.org/10.3390/parasitologia5020026 - 3 Jun 2025
Viewed by 238
Abstract
This study aimed to explore and identify soil-dwelling nematophagous fungi (NF) from the “El Texcal” Ecological Reserve in Morelos, Mexico, and evaluate their potential as biological control agents against Haemonchus contortus infective larvae (HcL3), a major parasitic threat in livestock systems. [...] Read more.
This study aimed to explore and identify soil-dwelling nematophagous fungi (NF) from the “El Texcal” Ecological Reserve in Morelos, Mexico, and evaluate their potential as biological control agents against Haemonchus contortus infective larvae (HcL3), a major parasitic threat in livestock systems. The fungi were isolated from soil using the sprinkling of soil on water agar plates. The identification of NF was achieved using morphological identification keys, which was corroborated by molecular procedures using the PCR technique in the ITS4 and ITS5 regions. The nematocidal effects occasioned by these NF were examined through their predatory activity (PA) against HcL3 on water agar plates, and additionally, the larval mortality attributed to their liquid filtrates (LFs) was assessed at three different concentrations (25, 50, and 100 mg/mL) on 96-well microtiter plates. Two NF were identified and classified as two species of Dactylellina genus, namely D. haptospora (Dh) and D. phymatopaga (Dp). The PA exhibited by these NF were 94.79% for Dh and 68.88% for Dp; while their LFs showed 27.83% mortality for Dh and 32.86% for Dp at the highest concentration assessed. While the PA was notably high, the moderate larvicidal effect of the LF suggests that their efficacy may primarily rely on direct physical interaction rather than metabolite-mediated toxicity. The high PA demonstrated by these two isolates of NF indicates that they could be effective candidates for biological control agents against HcL3. Full article
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