Interactions of Intestinal Microbiomes, Hosts and Nutritional Factors Involved in Liver Physiology
A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Prebiotics and Probiotics".
Deadline for manuscript submissions: 20 October 2025 | Viewed by 25
Special Issue Editor
Interests: liver cancer; liver transplantation; liver cirrhosis; liver diseases and immunology; cirrhosis; hepatitis B; gastroenterology; hepatology; hepatitis C; hepatocellular carcinoma
Special Issue Information
Dear Colleagues,
The gut and liver are closely connected through the gut–liver axis, created by the portal circulation that transports nutrients, microbial metabolites, and toxic substances, and the biliary enterohepatic circulation. The intestinal microbiome plays a crucial role in regulating liver physiology, influencing processes such as lipid metabolism, gluconeogenesis, and detoxification. Alterations in microbiota composition (dysbiosis) can lead to inflammation and liver diseases such as metabolic-associated steatotic liver disease (MASLD), cirrhosis, and chronic hepatitis. Microbial metabolites, including short-chain fatty acids, endotoxins, and modified bile acids, modulate immune function and intestinal barrier integrity. Nutritional factors, such as the intake of fibers, fats, and sugars, directly affect the microbiome and indirectly impact liver health. Recent studies suggest that targeted interventions on the gut microbiota, including fecal microbiota transplantation, may represent promising therapeutic strategies for liver diseases.
This Special Issue aims to provide a comprehensive understanding of the intricate interactions between the intestinal microbiome, host physiology, and nutritional factors involved in liver function. We encourage the submission of original research articles, reviews, and systematic reviews covering a wide range of related topics.
Prof. Dr. Francesca Romana Ponziani
Guest Editor
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Keywords
- gut–liver axis
- gut microbiome
- liver physiology
- liver diseases
- dysbiosis
- metabolic-associated steatotic liver disease (MASLD)
- cirrhosis
- chronic hepatitis
- nutritional factors
- diet and microbiome
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