Nutritional Modulation of Glucose Metabolism and Metabolic Disease: Dietary Patterns, Bioactive Compounds, and Underlying Mechanisms

Dear Colleagues,

Metabolic diseases, including type 2 diabetes, metabolic dysfunction-associated steatotic liver disease (MASLD), and metabolic syndrome, have reached alarming global prevalence, driven in part by unhealthy dietary habits and lifestyle factors. Dysregulated glucose metabolism lies at the core of these conditions, and nutrition is a key modulator of glycemic control and metabolic health. Both overall dietary patterns and specific bioactive food components can profoundly influence insulin sensitivity, blood glucose regulation, and disease risk. This Special Issue focuses on how dietary patterns—ranging from traditional Mediterranean and plant-based diets to emerging nutritional strategies—can improve glucose homeostasis and mitigate metabolic disease. We welcome both basic and clinical studies, including human trials, animal models, and cellular investigations, as well as high-quality reviews. Submissions addressing bioactive compounds such as dietary fibers, functional foods, polyphenols, and micronutrients are encouraged, particularly those elucidating mechanisms involving gut microbiota, hormonal regulation, mitochondrial function and biogenesis, endoplasmic reticulum stress, oxidative stress, inflammation, and related gene and protein regulation. By integrating mechanistic and translational perspectives, this Special Issue aims to advance nutrition-based strategies for the prevention and management of glucose-related metabolic diseases. We invite researchers from diverse disciplines to submit their original research and review articles.

Dr. Hossein Rafiei
Guest Editor

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