New Insights into Nano Nutraceuticals

A special issue of Nutraceuticals (ISSN 1661-3821).

Deadline for manuscript submissions: closed (31 December 2025) | Viewed by 2661

Special Issue Editor


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Guest Editor
Department of Life and Environmental Sciences, University of Cagliari, 09124 Cagliari, Italy
Interests: drug delivery; nano carriers; antioxidants; pharmaceutical technology
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Special Issue Information

Dear Colleagues,

The increasing prevalence of chronic diseases, aging-related disorders, and lifestyle-induced oxidative stress has spurred interest in the use of nutraceuticals as preventive and therapeutic agents. However, the potential of these compounds is often hindered by their poor bioavailability, low water solubility, and instability during storage or in physiological environments.

Recent advances in nanotechnology have opened new horizons for the development of nano nutraceuticals. By reducing particle size to the nanometer scale and encapsulating active ingredients in specialized delivery systems, such as liposomes, nanoemulsions, solid lipid nanoparticles (SLNs), and nanostructured lipid carriers (NLCs), it is now possible to enhance the solubility, stability, and controlled release of nutraceutical compounds. These technologies have the potential to significantly improve nano nutraceuticals’ efficacy for applications in health, wellness, and disease management.

This Special Issue, entitled “New Insights into Nano Nutraceuticals”, aims to provide an overview of the latest research and innovations in this field. We invite researchers to contribute original research articles or reviews on topics that include, but are not limited to, the following:

  • The development of nanoformulations for nutraceutical delivery;
  • Applications of nano nutraceuticals to address oxidative stress, inflammation, and metabolic disorders;
  • Advances in encapsulation techniques for nutraceuticals;
  • Stability and bioavailability studies of nano nutraceuticals;
  • Nano nutraceuticals for cosmeceutical applications;
  • Regulatory and safety aspects of nano nutraceuticals;
  • Industrial scalability and sustainability in nano nutraceutical production.

Dr. Matteo Perra
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutraceuticals is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nano nutraceuticals
  • antioxidants
  • liposomes
  • solid lipid nanoparticles (SLNs)
  • nanostructured lipid carriers (NLCs)
  • nutraceutical bioavailability
  • oxidative stress
  • functional foods
  • controlled release systems
  • nanoemulsions

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Published Papers (1 paper)

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Research

12 pages, 2612 KB  
Article
A Novel Liposomal Palmitoylethanolamide (PEA) with Enhanced Gastrointestinal Permeating Properties
by Giada Ceccarelli, Chiara Pennetta, Francesco Montalbano, Mariano Licciardi, Valentina Melfi and Rossana G. Iannitti
Nutraceuticals 2025, 5(4), 34; https://doi.org/10.3390/nutraceuticals5040034 - 20 Oct 2025
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Abstract
Palmitoylethanolamide (PEA) is a naturally occurring fatty acid amide and an endocannabinoid-related lipid that has been extensively studied for its analgesic, immunomodulatory, antimicrobial, and anti-inflammatory properties. It has demonstrated efficacy in various applications and is currently utilized as a nutraceutical for its antinociceptive, [...] Read more.
Palmitoylethanolamide (PEA) is a naturally occurring fatty acid amide and an endocannabinoid-related lipid that has been extensively studied for its analgesic, immunomodulatory, antimicrobial, and anti-inflammatory properties. It has demonstrated efficacy in various applications and is currently utilized as a nutraceutical for its antinociceptive, neuroprotective, and immunomodulatory effects, particularly in supporting brain and joint health and in mitigating inflammatory processes. Background/Objectives: Despite its significant therapeutic potential, the clinical effectiveness of PEA is limited by its poor water solubility and, consequently, low oral bioavailability. Additionally, degradation in the acidic gastrointestinal environment further compromises its absorption. To address these challenges, several technological strategies have been explored to improve its pharmacokinetic profile, including conventional micronization and ultra-micronization techniques. The objective of this study was to characterize a novel liposomal formulation based on PEA and evaluate its intestinal permeation and absorption. Methods: Comparative permeation studies of PEA were conducted using ex vivo models to evaluate its absorption characteristics across gastrointestinal mucosae. The experiments were performed in a Franz diffusion cell system using a porcine colon mucosa in two physiologically relevant media: Simulated Gastric Fluid (SGF) and Fasted State Simulated Intestinal Fluid (FaSSIF). Results: Liposomal PEA showed a more efficient and continuous release over time, reaching higher concentrations of PEA permeated through the membrane. Conclusions: Our findings demonstrate a significant improvement in PEA’s permeability and absorption in an ex vivo simulated gastrointestinal environment. Liposomal PEA appears to be more affine to biological membranes. These results suggest that liposomal PEA may represent a promising therapeutic strategy for managing chronic pain and inflammatory conditions such as chronic pelvic pain. Full article
(This article belongs to the Special Issue New Insights into Nano Nutraceuticals)
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