Epigenetics of Sleep Disorders
A special issue of Neurology International (ISSN 2035-8377).
Deadline for manuscript submissions: closed (31 January 2022) | Viewed by 3978
Special Issue Editor
Interests: epigenomics; sleep disorders; multiomics; obstructive sleep apnea; developmental origin of diseases; circulating DNA; liquid biopsies; cognitive disorders; cardiometabolic disorders; cancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Sleep disorders are common conditions disturbing sleep patterns in adults and children. They represent a wide spectrum including sleep disruption, insomnia, restless leg syndrome, hypersomnia (e.g., narcolepsy), circadian rhythm disorders, parasomnias, and sleep disordered breathing (e.g., sleep apnea). Sleep disorders entail problems with the quality, timing, and amount of sleep, which result in daytime distress and impairment in functioning. Furthermore, numerous and serious morbidities are associated with sleep disorders, virtually affecting every organ and system. Sleep disorders have been associated with the occurrence of metabolic, cardiovascular, and cognitive disorders, as well as tumor aggressiveness and poor prognosis in cancer.
Epigenetics refers to the study of heritable changes in genome function that occur without a change in DNA sequence. Assessment and evaluation of epigenomic profiles have currently a fundamental role in understanding, diagnosing, and treating complex pathologies. Changes in epigenetic profiles are among the most common molecular alterations in virtually all complex diseases including cancer, diabetes, metabolic syndrome, atherosclerosis, inflammatory bowel disease, autoimmune diseases, and psychiatric and neurodegenerative disorders. The role of epigenetic regulation in sleep disorders is starting to be recognized. New diagnostic opportunities may arise from the identification of epigenetic alterations that may provide high sensitivity and specificity for detecting, monitoring, and predicting the outcome of sleep disorders.
This Special Issue is dedicated to reviewing and presenting new data from current research on the role of epigenetics in the pathophysiology of sleep disorders and the application of epigenetic markers for the diagnosis of sleep disorders and their comorbidities.
You may choose our Joint Special Issue in Diagnostics.
Dr. Rene Cortese
Guest Editor
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Keywords
- DNA methylation
- Histone modifications
- Non-coding RNA
- Epigenetics
- Sleep disorders
- Molecular diagnostics
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