Small RNAs – Big Roles: IsomiRs, tRNA Fragments, and rRNA Fragments in Human Health and Disease
A special issue of Non-Coding RNA (ISSN 2311-553X). This special issue belongs to the section "Small Non-Coding RNA".
Deadline for manuscript submissions: closed (30 December 2023) | Viewed by 11270
Special Issue Editors
Interests: next-generation sequencing; microRNAs; non-coding RNAs; transcriptome; bioinformatics
Special Issues, Collections and Topics in MDPI journals
Interests: microRNAs; noncoding RNA; gene expression; cell signalling
Special Issues, Collections and Topics in MDPI journals
Interests: short non-coding RNA, cyclic phosphate-containing RNA, tRNA-derived RNA, tRNA half
Interests: microRNAs (miRNAs) and miRNA isoforms (isomiRs); tRNA-derived fragments (tRFs); rRNA-derived fragments (rRFs); post-transcriptional regulation; pyknons; repetitive elements; genomic architecture
Special Issue Information
Dear Colleagues,
Small RNAs are known to play essential roles in numerous cellular contexts. Among the various RNA classes, the microRNAs (miRNAs) and their isoforms (isomiRs), the tRNA-derived fragments (tRFs), and the rRNA-derived fragments (rRFs) have been attracting much attention during the last decade. Quickly accumulating evidence suggests that all three classes are useful for designing powerful diagnostics and prognostics and as novel therapeutic targets.
IsomiRs, tRFs, and rRFs arise non-randomly from miRNA precursors, tRNAs, and rRNAs, respectively. Which of these small RNAs are produced from a precursor molecule and at what abundance level depends on personal attributes (e.g., biological sex, ancestry, age) and context (e.g., cell type, disease type/subtype). Moreover, while some isomiRs, tRFs, and rRFs regulate mRNA and protein levels through RNA interference, it is unclear how most of them function.
This Special Issue of “Noncoding RNA” focuses on isomiRs, tRFs, and rRFs and the many open questions surrounding them. Manuscripts reporting original research, short communications, and methods will be of particular interest. Focused reviews will also be considered.
The following is a non-exhaustive list of themes of interest:
- Novel insights into the biogenesis of isomiRs, tRFs, and rRFs.
- Novel insights into how isomiRs, tRFs, and rRFs regulate gene expression.
- Previously unreported patterns of expression in health and disease.
- Reports of novel disease biomarkers or prognostics based on these small RNAs.
- Functionalization of specific small RNAs.
- Evolutionary aspects of isomiRs, tRNA fragments, and rRNA fragments.
- Experimental methods for the accurate detection and quantification of these small RNAs.
Dr. Eric Londin
Dr. Cameron Bracken
Dr. Yohei Kirino
Dr. Isidore Rigoutsos
Guest Editors
Manuscript Submission Information
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Keywords
- microRNA
- miRNA
- miRNA isoform
- isomiR
- tRNA
- tRNA-derived fragment
- tRF
- rRNA
- rRNA-derived fragment
- rRF
- biomarker
- diagnostic
- prognostic
- therapeutic
- small RNA
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