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Noble Metal and Metal Oxide Nanoparticles and Their Nano-Composites for Catalytic and Biomedical Applications

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A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Synthesis, Interfaces and Nanostructures".

Deadline for manuscript submissions: closed (31 March 2021) | Viewed by 5080

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Special Issue Editor

Prof. Dr. Carola Kryschi

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Guest Editor

Department Chemistry and Pharmacy, Friedrich-Alexander University of Erlangen, Erlangen, Germany
Interests: redoxactive nanoparticles; magnetoplasmonic nanoheterostructures; X-ray enhancing nanoagents; X-ray triggered drug release; multimodal nanothernostics

Special Issue Information

Dear Colleagues,

Noble metal and metal oxide nanostructures, especially combined in core−shell, onion-, dumbbell-, flower-like heterodimers, represent highly inspiring nanoplatforms for multiple applications in heterogeneous catalysis, environmental sciences, biology and medicine. Suitable metal oxide nanomaterials are TiO₂, Ce2O₃, MoO_3-x, V₂O₅, WO_3-x, BiOI, MnFe₂O₄, ZnFe₂O₄ and Fe₃O₄ nanoparticles as being redox active. Beyond that, Fe3O4, MnFe₂O₄, and ZnFe₂O₄ (ferrite) nanoparticles exhibit superparamagnetism or ferrimagnetism which enable biomedical applications including magnetic separation techniques, magnetic drug targeting, magnetofection and magnetic hyperthermia. On the other hand, plasmonic nanostructures, comprising spherical, core-shell, rod-like and star-shaped gold, platinum and palladium nanoparticles, provide unique interactions with light which enable controllable plasmonic heating (of tumor tissue) and versatile photocatalytic applications. The combination of plasmonic and redox active metal oxide nanostructures enhances the catalytic performance due to interfacial electron transfer and for photocatalysis, due to the expansion of the spectrum for light absorption to the visible and NIR range. In addition, localized surface plasmons enhance magneto-optical responses, such as Faraday, Kerr, Cotton−Mouton and Voigt effects providing powerful probes for the magnetic state of nanocomposites. These magneto-optical phenomena may be exploited to control the polarization and/or intensity of light. Magnetoplasmonic nanocomposites as consisting of ferrite fused with Au-, Pd- or Pt nanoparticles possess novel interfacial electronic and electromagnetic interactions which modify the redox potential and thereupon, may significantly improve the catalytic performance of the nanoheterostructure. The superparamagnetism of the ferrite component facilitates prospective applications in medicine as being magnetic protein separation, magnetic hyperthermia, magnetic drug delivery and others. Moreover, magnetoplasmonic nanocomposites are predestined for operating as contrast agents in MRI and CT. Under X-ray exposure intracellular Au-Fe3O4 nanoheterodimers simultaneously act as Fenton catalyst and Auger/Compton electron emitter, and thus, are auspicious X-ray enhancing agents in low-dose radiation therapy.

This multidisciplinary Special Issue on Noble Metal and Metal Oxide Nanostructures focuses on controllable syntheses of redoxactive noble-metal metal oxide nanoheterostuctures for feasible applications in photocatalysis (H2 and solar energy generation), magneto-optics and opto-magnetism and as theranostics in cancer medicine. Interdisciplinary working scientists are encouraged to submit original research articles and review articles.

Prof. Dr. Carola Kryschi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

Redox active metal oxide nanoparticles
Magnetoplasmonic nanoparticles
Magnetic data storage
Magneto-optics
Magneto-optical Kerr and Cotton-Mouton effect
Magnetically recyclable catalysis
Nanomedicine
Magnetic protein separation
Theranostics nanomaterials
MRI/CT contrast agents
Magnetic hyperthermia
Magnetic drug targeting
Magnetofection
X-ray dose enhancing nanomaterial
X-ray triggered drug release

Published Papers (2 papers)

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Research

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19 pages, 4157 KiB

Open AccessArticle

Caffeic Acid, Quercetin and 5-Fluorocytidine-Functionalized Au-Fe₃O₄ Nanoheterodimers for X-ray-Triggered Drug Delivery in Breast Tumor Spheroids

by Stefanie Klein, Luitpold V. R. Distel, Winfried Neuhuber and Carola Kryschi

Nanomaterials 2021, 11(5), 1167; https://doi.org/10.3390/nano11051167 - 29 Apr 2021

Cited by 8 | Viewed by 2342

Abstract

Au-Fe₃O₄ nanoheterodimers (NHD) were functionalized with the natural and synthetic anticancer drugs caffeic acid (CA), quercetin (Q) and 5-fluorocytidine (5FC). Their X-radiation dose-enhancing potential and chemotherapeutic efficacy for bimodal cancer therapy were investigated by designing multicellular tumor spheroids (MCTS) to in vitro avascular tumor models. MCTS were grown from the breast cancer cell lines MCF-7, MDA-MB-231, and MCF-10A. The MCF-7, MDA-MB-231 and MCF-10A MCTS were incubated with NHD-CA, NHD-Q, or NHD-5FC and then exposed to fractionated X-radiation comprising either a single 10 Gy dose, 2 daily single 5 Gy doses or 5 daily single 2 Gy doses. The NHD-CA, NHD-Q, and NHD-5FC affected the growth of X-ray irradiated and non-irradiated MCTS in a different manner. The impact of the NHDs on the glycolytic metabolism due to oxygen deprivation inside MCTS was assessed by measuring lactate secretion and glucose uptake by the MCTS. The NHD-CA and NHD-Q were found to act as X-radiation dose agents in MCF-7 MCTS and MDA-MB-231 MCTS and served as radioprotector in MCF-10A MCTS. X-ray triggered release of CA and Q inhibited lactate secretion and thereupon disturbed glycolytic reprogramming, whereas 5FC exerted their cytotoxic effects on both, healthy and tumor cells, after their release into the cytosol. Full article

(This article belongs to the Special Issue Noble Metal and Metal Oxide Nanoparticles and Their Nano-Composites for Catalytic and Biomedical Applications)

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Review

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52 pages, 11044 KiB

Open AccessReview

Synthetic Approaches to Colloidal Nanocrystal Heterostructures Based on Metal and Metal-Oxide Materials

by Concetta Nobile and Pantaleo Davide Cozzoli

Nanomaterials 2022, 12(10), 1729; https://doi.org/10.3390/nano12101729 - 18 May 2022

Cited by 6 | Viewed by 2319

Abstract

Composite inorganic nanoarchitectures, based on combinations of distinct materials, represent advanced solid-state constructs, where coexistence and synergistic interactions among nonhomologous optical, magnetic, chemical, and catalytic properties lay a basis for the engineering of enhanced or even unconventional functionalities. Such systems thus hold relevance for both theoretical and applied nanotechnology-based research in diverse areas, spanning optics, electronics, energy management, (photo)catalysis, biomedicine, and environmental remediation. Wet-chemical colloidal synthetic techniques have now been refined to the point of allowing the fabrication of solution free-standing and easily processable multicomponent nanocrystals with sophisticated modular heterostructure, built upon a programmed spatial distribution of the crystal phase, composition, and anchored surface moieties. Such last-generation breeds of nanocrystals are thus composed of nanoscale domains of different materials, assembled controllably into core/shell or heteromer-type configurations through bonding epitaxial heterojunctions. This review offers a critical overview of achievements made in the design and synthetic elaboration of colloidal nanocrystal heterostructures based on diverse associations of transition metals (with emphasis on plasmonic metals) and transition-metal oxides. Synthetic strategies, all leveraging on the basic seed-mediated approach, are described and discussed with reference to the most credited mechanisms underpinning regioselective heteroepitaxial deposition. The unique properties and advanced applications allowed by such brand-new nanomaterials are also mentioned. Full article

(This article belongs to the Special Issue Noble Metal and Metal Oxide Nanoparticles and Their Nano-Composites for Catalytic and Biomedical Applications)

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