Nanomaterials in Modern Immunotherapy: Innovations, Applications, and Future Perspectives
A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".
Deadline for manuscript submissions: 20 March 2026 | Viewed by 33
Special Issue Editors
Interests: nanomedicine; targeted drug delivery; bioanalysis; formulation and development; physiologically based pharmacokinetic modeling and simulation; PKPD; QSP
Special Issues, Collections and Topics in MDPI journals
Interests: formulation; drug delivery; nanomedicine; pharmacokinetics; biopharmaceutics; PBBK modeling; AI in drug delivery
Interests: drug formulation and delivery; topical and transdermal; clinical pharmacy; pharmaceutical analysis and QA; application of AI in drug delivery
Special Issue Information
Dear Colleagues,
The convergence of nanotechnology and immunology has catalyzed a new era of therapeutic interventions, offering unprecedented precision and efficacy. Nanomaterials are at the forefront of this revolution, engineered to modulate immune responses, enhance the delivery of therapeutics, and overcome the limitations of conventional treatments for a host of diseases, most notably cancer. The unique physicochemical properties of nanomaterials allow for the design of sophisticated systems capable of targeted delivery to specific immune cells, controlled release of immunomodulatory agents, and the co-delivery of antigens and adjuvants to elicit robust and durable immune responses.
Recent advancements have highlighted the potential of various nanoplatforms, including lipid-based nanoparticles, polymeric nanocarriers, and inorganic nanomaterials in applications such as cancer vaccines, adoptive cell therapies, and immune checkpoint blockade. These technologies are not only improving the therapeutic window of existing immunotherapies but are also enabling novel strategies like personalized cancer vaccines based on neoantigens.
This Special Issue aims to bring together cutting-edge research and comprehensive reviews that explore the latest developments in the application of nanomaterials in immunotherapy. We invite contributions that cover the design, characterization, and application of nanomaterials for immunomodulation. We welcome both original research articles and review papers. Potential topics include, but are not limited to, the following:
- Design and synthesis of novel immunomodulatory nanomaterials;
- Nanoparticle-based cancer vaccines (including mRNA, peptide, and whole-cell vaccines) ;
- Targeted delivery of immune checkpoint inhibitors using nanocarriers;
- Nanomaterials for enhancing adoptive cell therapies (e.g., CAR-T);
- Smart nanomaterials responsive to the tumor microenvironment;
- Inorganic and organic nanoparticles in immunotherapy (e.g., gold nanoparticles, liposomes, polymers);
- Nanomaterials for modulating the tumor microenvironment and targeting cancer-associated fibroblasts;
- Preclinical and clinical studies of nano-immunotherapeutics;
- Safety, toxicity, and regulatory aspects of immunomodulatory nanomaterials;
- Multifunctional nanomaterials for combined chemo-immunotherapy or theranostics.
Dr. Nitin Charbe
Dr. Sushesh Srivatsa Palakurthi
Guest Editors
Dr. Sumedha Kapre
Guest Editor Assistant
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cancer immunotherapy
- immune checkpoint inhibitors
- nanoparticle drug delivery
- tumor microenvironment
- dendritic cell targeting
- vaccine adjuvants
- immunomodulation
- cytokine delivery
- macrophage repolarization
- clinical translation
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