Multi-Omics in Health and Disease

A special issue of Methods and Protocols (ISSN 2409-9279).

Deadline for manuscript submissions: closed (15 December 2019) | Viewed by 3000

Special Issue Editors


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Guest Editor
Computer Science Research Institute, Ulster University, Newtownabbey, UK
Interests: bioinformatics; artificial intelligence; integrative data analytics

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Guest Editor
School of Computing, Ulster University, Belfast BT15 1AP, UK
Interests: machine learning; bioinformatics; healthcare informatics; healthcare technology; intelligent data analysis; integrative data analytics; assistive technologies
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Special Issue Information

Dear Colleagues,

The past decade has seen advances in technologies such as high-throughput sequencing and mass spectrometry, resulting in large-scale production of “omic” data. Technologies can capture “omic” data across various cellular levels, including the genome, epigenome, transcriptome, proteome, and metabolome. Individually, these technologies have advanced our understanding of disease and are beginning to enable the era of precision medicine. However, no one technology can capture the full complexity and heterogeneity of disease. To provide a more comprehensive view of human health and disease, the integration of multi-omics data has been proposed to understand, diagnose, and aid in providing targeted treatment/prevention plans to patients. To address this challenge, a multi-disciplinary cutting-edge research effort is required. This should combine different scientific disciplines such as bioinformatics, computing medicine, chemistry, and mathematics.

In this Special Issue titled “Multi-Omics in Health and Disease”, we welcome original research and review articles presenting novel computational and bioinformatics methodologies and algorithmic approaches that address the challenges in (1) multi-omics and clinical data integration, (2) handling heterogenous multi-omics big data, (3) bioinformatics tools to integrate and visualise multi-omics biological data, (4) multi-omics data sharing, standards, privacy, and protection, (5) applications of multi-omics approaches to improving our understanding of disease mechanisms and their integration into clinical practice.


Dr. Fiona Browne
Prof. Huiru Zheng
Guest Editors

Manuscript Submission Information

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Keywords

  • multi-omics integration
  • big data
  • integrative analysis
  • healthcare
  • disease
  • genomics
  • epigenomics
  • proteomics
  • metabolomics

Published Papers (1 paper)

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Research

12 pages, 435 KiB  
Article
Uncovering Effects from the Structure of Metabarcode Sequences for Metagenetic and Microbiome Analysis
by David C. Molik, Michael E. Pfrender and Scott J. Emrich
Methods Protoc. 2020, 3(1), 22; https://doi.org/10.3390/mps3010022 - 12 Mar 2020
Cited by 4 | Viewed by 2504
Abstract
The advent of next-generation sequencing has allowed for higher-throughput determination of which species live within a specific location. Here we establish that three analysis methods for estimating diversity within samples—namely, Operational Taxonomic Units; the newer Amplicon Sequence Variants; and a method commonly found [...] Read more.
The advent of next-generation sequencing has allowed for higher-throughput determination of which species live within a specific location. Here we establish that three analysis methods for estimating diversity within samples—namely, Operational Taxonomic Units; the newer Amplicon Sequence Variants; and a method commonly found in sequence analysis, minhash—are affected by various properties of these sequence data. Using simulations we show that the presence of Single Nucleotide Polymorphisms and the depth of coverage from each species affect the correlations between these approaches. Through this analysis, we provide insights which would affect the decisions on the application of each method. Specifically, the presence of sequence read errors and variability in sequence read coverage deferentially affects these processing methods. Full article
(This article belongs to the Special Issue Multi-Omics in Health and Disease)
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