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Special Issue "Thin-Film Nanomaterials: Applications in Biotechnology"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Nanochemistry".

Deadline for manuscript submissions: 31 December 2022 | Viewed by 1148

Special Issue Editors

Dr. Anton M. Manakhov
E-Mail Website
Guest Editor
1. Research Institute of Clinical and Experimental Lymphology—Branch of the ICG SB RAS, 2 Timakova St., 630060 Novosibirsk, Russia
2. Aramco Innovations LLC, Moscow, Russia
Interests: plasma chemistry; surface characterization; thin films; nanomaterials; bio-application of plasma polymers
Special Issues, Collections and Topics in MDPI journals
Dr. Elizaveta Permyakova
Assistant Guest Editor
Research Institute of Clinical and Experimental Lymphology– Branch of the ICG SB RAS, Novosibirsk, Russia
Interests: biotechnology; cell biology; nanofibers; nanoparticles; cancer treatment
Mr. Miroslav Michlíček
E-Mail Website
Assistant Guest Editor
Masaryk University, Brno, Czech Republic
Interests: Material Characterization; Materials Science; Polymerization; Nanomaterials; Materials Chemistry; Materials; Thin Films; Polymers; Thin Films and Nanotechnology; Nanomaterials Synthesis

Special Issue Information

Dear Colleagues,

Thin-film nanomaterials are a quickly growing area of research and technology. Such nanomaterials include 2D materials (graphene, MoS2), nanotubes, nanowires, and nanofibers. Often, these materials must be additionally modified (e.g., by thin layers and films) in order to induce specific properties, for example, to immobilize antibodies, DNA, proteins, etc. These thin-film-modified nanomaterials open a new area of research for biosensors, tissue engineering, drug delivery, and many others. In this Issue, interdisciplinary research in the field of nanomaterials for biosensing, enhanced cell adhesion, wound therapy, theranostics, cancer treatment, antimicrobial layers, and biomolecule detection are warmly welcome.

Dr. Anton M. Manakhov
Dr. Elizaveta Permyakova
Dr. Miroslav Michlíček
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2300 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Tissue engineering
  • 2D materials
  • Antibacterial layers

Published Papers (1 paper)

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Biodegradable Nanohybrid Materials as Candidates for Self-Sanitizing Filters Aimed at Protection from SARS-CoV-2 in Public Areas
Molecules 2022, 27(4), 1333; - 16 Feb 2022
Viewed by 636
The COVID-19 pandemic has raised the problem of efficient, low-cost materials enabling the effective protection of people from viruses transmitted through the air or via surfaces. Nanofibers can be a great candidate for efficient air filtration due to their structure, although they cannot [...] Read more.
The COVID-19 pandemic has raised the problem of efficient, low-cost materials enabling the effective protection of people from viruses transmitted through the air or via surfaces. Nanofibers can be a great candidate for efficient air filtration due to their structure, although they cannot protect from viruses. In this work, we prepared a wide range of nanofibrous biodegradable samples containing Ag (up to 0.6 at.%) and Cu (up to 20.4 at.%) exhibiting various wettability. By adjusting the magnetron current (0.3 A) and implanter voltage (5 kV), the deposition of TiO2 and Ag+ implantation into PCL/PEO nanofibers was optimized in order to achieve implantation of Ag+ without damaging the nanofibrous structure of the PCL/PEO. The optimal conditions to implant silver were achieved for the PCL-Ti0.3-Ag-5kV sample. The coating of PCL nanofibers by a Cu layer was successfully realized by magnetron sputtering. The antiviral activity evaluated by widely used methodology involving the cultivation of VeroE6 cells was the highest for PCL-Cu and PCL-COOH, where the VeroE6 viability was 73.1 and 68.1%, respectively, which is significantly higher compared to SARS-CoV-2 samples without self-sanitizing (42.8%). Interestingly, the samples with implanted silver and TiO2 exhibited no antiviral effect. This difference between Cu and Ag containing nanofibers might be related to the different concentrations of ions released from the samples: 80 μg/L/day for Cu2+ versus 15 µg/L/day for Ag+. The high antiviral activity of PCL-Cu opens up an exciting opportunity to prepare low-cost self-sanitizing surfaces for anti-SARS-CoV-2 protection and can be essential for air filtration application and facemasks. The rough cost estimation for the production of a biodegradable nanohybrid PCL-Cu facemask revealed ~$0.28/piece, and the business case for the production of these facemasks would be highly positive, with an Internal Rate of Return of 34%. Full article
(This article belongs to the Special Issue Thin-Film Nanomaterials: Applications in Biotechnology)
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