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Anti-obesity Effects of Natural Compounds
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Anti-obesity Effects of Natural Compounds

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (30 August 2021) | Viewed by 13406

Special Issue Editor

Prof. Dr. Sun-Shin Yi

E-Mail Website
Guest Editor
Department of Biomedical Laboratory Science, College of Medical Sciences, Soonchunhyang University, Asan 31538, Korea
Interests: brain functions by anti-obesity natural compounds; eating behaviors and neuropeptide alterations by bioactive bioactives in anti-obesity; thermogenesis alterations by any molecules having anti-obesity effects; inflammatory responses by any molecules having anti-obesity effects; novel besity-related genes studies by genetical engineered mice (GEM) resources with novel molecules

Special Issue Information

Dear Colleagues,

Recently, obesity has become a risk factor that causes various diseases, resulting in huge social costs worldwide. Obesity is basically caused by an imbalance in energy intake and expenditure; however, simply stating this cannot solve the problem of obesity. It can be exacerbated by psychological, inflammatory response, thermogenic, and brain function changes. Behavioral changes that control appetite have also been of interest in recent research. Therefore, obesity cannot be overcome by the will of a patient who cannot control his/her appetite, and the study of the diverse factors surrounding the patient is essential.

Natural products are gaining popularity in the anti-obesity market. More studies are dealing with diet pills that prevent or control obesity through chemical reaction strategies, or finding natural bioactive agents of natural origin. Additionally, attention is being paid to the additional effects these beneficial substances can have with regard to reducing obesity. It is expected that such research will be good news for more people if it can be combined with the function of the genes associated with obesity.

Prof. Dr. Sun-Shin Yi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Eating-behaviors
  • Thermogenesis
  • Brain function
  • Appetite
  • Inflammatory response
  • Natural compounds
  • Obesity

Published Papers (3 papers)

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Research

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14 pages, 6871 KiB  
Article
Protective Effects of Polyphenol Enriched Complex Plants Extract on Metabolic Dysfunctions Associated with Obesity and Related Nonalcoholic Fatty Liver Diseases in High Fat Diet-Induced C57BL/6 Mice
by Ahtesham Hussain, Jin Sook Cho, Jong-Seok Kim and Young Ik Lee
Molecules 2021, 26(2), 302; https://doi.org/10.3390/molecules26020302 - 8 Jan 2021
Cited by 13 | Viewed by 3585
Abstract
Background: Currently, obesity is a global health challenge due to its increasing prevalence and associated health risk. It is associated with various metabolic diseases, including diabetes, hypertension, cardiovascular disease, stroke, certain forms of cancer, and non-alcoholic liver diseases (NAFLD). Objective: The aim of [...] Read more.
Background: Currently, obesity is a global health challenge due to its increasing prevalence and associated health risk. It is associated with various metabolic diseases, including diabetes, hypertension, cardiovascular disease, stroke, certain forms of cancer, and non-alcoholic liver diseases (NAFLD). Objective: The aim of this study to evaluate the effects of polyphenol enriched herbal complex (Rubus crataegifolius/ellagic acid, Crataegus pinnatifida Bunge/vitexin, chlorogenic acid, Cinnamomum cassiaa/cinnamic acid) on obesity and obesity induced NAFLD in the high-fat diet (HFD)-induced obese mouse model. Methods: Obesity was induced in male C57BL/6 mice using HFD. After 8 weeks, the mice were treated with HFD+ plants extract for 8 weeks. Body weight, food intake weekly, and blood sugar level were measured. After sacrifice, changes in the treated group’s liver weight, fat weight, serum biochemical parameters, hormone levels, and enzyme levels were measured. For histological analysis, tissues were stained with hematoxylin-eosin (H&E) and Oil Red-O. Results: Our results showed that the herbal complex ameliorated body weight and liver weight gain, and decreased total body fat in HFD-fed animals. Post prandial blood glucose (PBG) and fasting blood glucose (FBG) were lower in the herbal complex-treated group than in the HFD control group. Additionally, herbal formulation treatment significantly increased HDL levels in serum and decreased TC, TG, AST, ALT, deposition of fat droplets in the liver, and intima media thickness (IMT) in the aorta. Herbal complex increased serum adiponectin and decreased serum leptin. Herbal complex also increased carnitine palmityl transferase (CPT) activity and significantly decreased enzyme activity of beta-hydroxy beta methyl glutamyl-CoA (HMG-CoA) reductase, and fatty acid synthase (FAS). Conclusions: The results of this study demonstrated that the herbal complex is an effective herbal formulation in the attenuation of obesity and obesity-induced metabolic dysfunction including NAFLD in HFD-induced mouse model. Full article
(This article belongs to the Special Issue Anti-obesity Effects of Natural Compounds)
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19 pages, 2234 KiB  
Article
Anti-Obesity and Gut Microbiota Modulation Effect of Secoiridoid-Enriched Extract from Fraxinus mandshurica Seeds on High-Fat Diet-Fed Mice
by Sen Guo, Haoan Zhao, Zhongxiao Ma, Shanshan Zhang, Mingrou Li, Zhaojing Zheng, Xiameng Ren, Chi-Tang Ho and Naisheng Bai
Molecules 2020, 25(17), 4001; https://doi.org/10.3390/molecules25174001 - 2 Sep 2020
Cited by 18 | Viewed by 3154
Abstract
Previously we conducted a phytochemical study on the seeds of Fraxinus excelsior and isolated nine secoiridoid compounds with adipocyte differentiation inhibitory activity and peroxisome proliferator activated receptor alpha (PPARα) activation effects. However, the bioactive constituents and functions of Fraxinus mandshurica seeds have not [...] Read more.
Previously we conducted a phytochemical study on the seeds of Fraxinus excelsior and isolated nine secoiridoid compounds with adipocyte differentiation inhibitory activity and peroxisome proliferator activated receptor alpha (PPARα) activation effects. However, the bioactive constituents and functions of Fraxinus mandshurica seeds have not been studied. In the present study, we investigated the secoiridoid compounds in F. mandshurica seed extract (FM) using column chromatography, 1H-NMR, 13C-NMR and HPLC-DAD methods. The pancreatic lipase inhibitory activities of isolated compounds were evaluated in vitro. Additionally, the anti-obesity and gut microbiota modulation effect of FM on high-fat diet-induced obesity in C57BL/6 mice were also studied in vivo. The results showed that 19 secoiridoids were isolated from FM and identified. The total content of secoiridoids in FM reached 181.35 mg/g and the highest content was nuzhenide (88.21 mg/g). All these secoiridoid compounds exhibited good pancreatic lipase inhibitory activity with inhibition rate ranged from 33.77% to 70.25% at the concentration of 100 μM. After obese mice were administrated with FM at 400 mg/kg.bw for 8 weeks, body weight was decreased by 15.81%. Moreover, FM could attenuate the lipid accumulation in serum and liver, relieve the damage in liver and kidney, and extenuate oxidative stress injury and inflammation caused by obesity in mice. FM could also modulate the structural alteration of gut microbiota in obese mice, increasing the proportion of anti-obesity gut microbiota (Bacteroidetes, Bacteroidia, S24-7 and Allobaculum), and reducing the proportion of obesogenic gut microbiota (Firmicutes and Dorea). This study suggests that F. mandshurica seeds or their secoiridoids may have potential for use as a dietary supplement for obesity management. Full article
(This article belongs to the Special Issue Anti-obesity Effects of Natural Compounds)
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Review

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28 pages, 1639 KiB  
Review
A Review on Obesity Management through Natural Compounds and a Green Nanomedicine-Based Approach
by Monika Bhardwaj, Poonam Yadav, Divya Vashishth, Kavita Sharma, Ajay Kumar, Jyoti Chahal, Sunita Dalal and Sudhir Kumar Kataria
Molecules 2021, 26(11), 3278; https://doi.org/10.3390/molecules26113278 - 28 May 2021
Cited by 30 | Viewed by 5965
Abstract
Obesity is a serious health complication in almost every corner of the world. Excessive weight gain results in the onset of several other health issues such as type II diabetes, cancer, respiratory diseases, musculoskeletal disorders (especially osteoarthritis), and cardiovascular diseases. As allopathic medications [...] Read more.
Obesity is a serious health complication in almost every corner of the world. Excessive weight gain results in the onset of several other health issues such as type II diabetes, cancer, respiratory diseases, musculoskeletal disorders (especially osteoarthritis), and cardiovascular diseases. As allopathic medications and derived pharmaceuticals are partially successful in overcoming this health complication, there is an incessant need to develop new alternative anti-obesity strategies with long term efficacy and less side effects. Plants harbor secondary metabolites such as phenolics, flavonoids, terpenoids and other specific compounds that have been shown to have effective anti-obesity properties. Nanoencapsulation of these secondary metabolites enhances the anti-obesity efficacy of these natural compounds due to their speculated property of target specificity and enhanced efficiency. These nanoencapsulated and naive secondary metabolites show anti-obesity properties mainly by inhibiting the lipid and carbohydrate metabolizing enzymes, suppression of adipogenesis and appetite, and enhancing energy metabolism. This review focuses on the plants and their secondary metabolites, along with their nanoencapsulation, that have anti-obesity effects, with their possible acting mechanisms, for better human health. Full article
(This article belongs to the Special Issue Anti-obesity Effects of Natural Compounds)
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