Innovations in Mass Spectrometry for Analytical Chemistry
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Analytical Chemistry".
Deadline for manuscript submissions: 30 June 2026 | Viewed by 15
Special Issue Editors
Interests: mass spectrometry; proteomics; metabolomics; single-cell mass spectrometry; mass spectrometry imaging
Special Issue Information
Dear Colleagues,
Mass spectrometry (MS) continues to be at the forefront of analytical chemistry, driving discoveries across chemical and biological sciences. Over the past decades, innovations in ionization methods, separation technologies, detector design, and data acquisition and processing have fundamentally transformed how we detect, identify, and quantify molecules in complex systems. The versatility of modern MS is hard to overstate. From deciphering chemical processes in the depths of the Earth’s crust and oceanic trenches to exploring extraterrestrial environments, from resolving the ancient chemical history preserved in fossils to characterizing atmospheric aerosols for climate modeling and prediction, and from observing the molecular phenotypes of whole organisms down to dissecting the inner workings of individual organelles, advances in MS technologies enable deeper insights into elemental and molecular composition and chemical reactions across diverse systems.
MS now integrates seamlessly with numerous ionization techniques and modes of sample introduction extending its analytical reach to a wide spectrum of molecular classes. Spatially resolved approaches have matured to allow direct mapping of biomolecules in tissues and can be performed routinely with single-cell and even subcellular resolution. The rise of advanced data-independent and data-dependent acquisition strategies, combined with new detector architectures and tools for data analysis, continues to improve sensitivity, coverage, and quantitative precision. Targeted approaches remain indispensable for precise and sensitive analyte quantitation, while untargeted workflows continuously establish new frontiers in analytical science.
This Special Issue, "Innovations in Mass Spectrometry for Analytical Chemistry", aims to capture recent progress and emerging directions across all aspects of mass spectrometry. We welcome original research, reviews, and communications addressing, but not limited to:
- Novel ionization techniques and ion sources;
- Advances in mass analyzers and detectors;
- Integration with chromatographic/electrophoretic separations;
- Ion-mobility and other types of gas-phase separations;
- Novel targeted and untargeted data acquisition strategies;
- Single-cell and spatial MS;
- Functional omics;
- Innovations in data analysis, algorithm development, statistics, and bioinformatics.
Prof. Dr. Claudia S. Maier
Guest Editor
Dr. Stanislau Stanisheuski
Guest Editor Assistant
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
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Keywords
- novel ionization techniques and ion sources
- advances in mass analyzers and detectors
- integration with chromatographic/electrophoretic separations
- ion-mobility and other types of gas-phase separations
- novel targeted and untargeted data acquisition strategies
- single-cell and spatial MS
- functional omics
- innovations in data analysis, algorithm development, statistics, and bioinformatics
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