Natural Products in Anti-obesity Therapy 2019
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".
Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 16522
Special Issue Editor
Special Issue Information
Dear Colleagues，
During the past several years, the worldwide prevalence of obesity has increased to such an extent that it has been declared an epidemic. Obesity is a multifactorial disease involving genetic eating behavior and endocrine factors. Obesity is characterized by a state of chronic low-grade inflammation. Onset of obesity is also associated with increased release of numerous inflammatory mediators from adipose tissus, production of reactive oxygen species (ROS) and diminished activity of antioxidant enzymes.Therefore, obesity is very often associated with a cluster of multiple ailments known as “the metabolic syndrome”.
In recent decades, a great deal of effort has therefore been focused on the use of different plant species because of their potent pharmacological activities, fewer side effects, and relatively low cost. Much of the therapeutic effect of medicinal plants has been attributed to the secondary metabolites (or phytochemicals) of the plants, such as terpenoids (including carotenoids), curcuminoids, alkaloids, and polyphenols. These phytochemicals have been shown to regulate fatty acid β-oxydation, and to couteract obesity-associated oxidative stress and inflammation. Various mechanisms of anti-obesity action of phytochemicals have been described. Phytochemicals have been shown to inhibit adipogenesis by regulating cell cycle and AMPKα signaling. It has been also reported that polyphenols and other phytochemicals modulate the NF-κB, PGE2, and COX2 pathways. Therefore, in this context, natural product research may lead to the development of new anti-obesity agents.
Dr. Aziz Hichami
Guest Editor
Manuscript Submission Information
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Keywords
- Obesity
- Inflammation
- Oxydative stress
- Lipid signalling
- Eating behavior
