Treatments Against Microorganisms of the Oral Cavity
A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Medical Microbiology".
Deadline for manuscript submissions: 30 June 2026 | Viewed by 9
Special Issue Editor
Interests: oral microbiology; potential malignant diseases; oral cancer; photodynamic therapy; tumors and lesions affecting the mandible
Special Issue Information
Dear Colleagues,
The oral cavity hosts a diverse microbiota, some of which are responsible for significant infectious diseases; therefore, effective treatment against these microorganisms is essential to preventing and managing conditions such as dental caries, periodontal disease, oral candidiasis, osteomyelitis, and medication-related osteonecrosis of the jaws (MRONJ). These pathogens often possess the ability to form complex biofilms, which act as protective barriers and substantially reduce the efficacy of conventional antimicrobial therapies. Biofilm-associated microorganisms exhibit increased resistance to antibiotics, antiseptics, and host immune responses, making their eradication particularly challenging.
Current treatment approaches include the mechanical removal of biofilms, the use of antimicrobial agents, antifungals, and, in severe cases, systemic therapies or surgical intervention. However, rising concerns surrounding antimicrobial resistance and the persistence of biofilm-embedded microorganisms underscore the need for the development of new therapeutic strategies. Emerging therapies—such as nanoparticles, photodynamic therapy, probiotics, and targeted antimicrobial peptides—are being explored as promising alternatives with enhanced specificity and reduced side effects.
Continuous evaluation and innovation in therapeutic options are crucial to improving clinical outcomes and reducing the global burden of oral infectious diseases, and advancing our understanding of microbial behavior and biofilm dynamics will guide the development of more effective and durable treatments.
Dr. Tulio Ferrisse
Guest Editor
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Keywords
- oral microbiota
- biofilms
- antimicrobial therapy
- dental caries
- periodontal disease
- candidiasis
- osteonecrosis
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