Emerging Fungal Pathogens, Diagnostic Innovations, and Clinical Strategies in the Era of Antifungal Resistance

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Medical Microbiology".

Deadline for manuscript submissions: 31 August 2026 | Viewed by 1363

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Department of Public Health and Pediatrics, Microbiology Division, University of Turin, 10126 Turin, Italy
Interests: mycology; bacteriology; essential oils; antifungal drugs; influence of antimicrobial drugs on the interaction between microorganisms and the immune system
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Special Issue Information

Dear Colleagues,

Fungal infections represent a growing global health threat, particularly with the emergence of new pathogenic species and the alarming rise in antifungal resistance. This Special Issue aims to highlight recent advances in the identification and management of fungal diseases, with a focus on innovative diagnostic tools, evolving clinical strategies, and novel therapeutic approaches to improve patient outcomes and to contain antifungal drug resistance.

This Special Issue focuses on the growing threat of emerging fungal pathogens, as well as well-known and common fungal species that continue to cause diseases. It highlights the importance of innovative diagnostics and clinical strategies to improve patient outcomes and to contain antifungal drug resistance. Researchers and clinicians are invited to submit contributions that address current challenges and advances in this critical field.

We are pleased to invite you to contribute original research articles, reviews, and case reports that address key challenges and opportunities in this important evolving field. Your work will help shape a more effective and informed response to one of today’s most pressing medical concerns.

We look forward to receiving your contributions.

Prof. Dr. Vivian Tullio
Guest Editor

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Keywords

  • emerging fungal pathogens
  • common fungal pathogens
  • resistance
  • diagnostic innovations
  • clinical strategies

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Published Papers (1 paper)

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Research

24 pages, 7761 KB  
Article
Spt7 Deletion Reveals Vulnerabilities in Cryptococcus neoformans Stress Adaptation and Virulence
by Chendi Katherine Yu, Christina J. Stephenson, Benjamin L. Schulz and James A. Fraser
Microorganisms 2026, 14(1), 95; https://doi.org/10.3390/microorganisms14010095 - 1 Jan 2026
Viewed by 980
Abstract
The Spt-Ada-Gcn5 acetyltransferase (SAGA) complex is a conserved transcriptional coactivator that coordinates histone modifications and transcriptional regulation in eukaryotes. In Cryptococcus neoformans, SAGA governs key virulence traits, yet the roles of several core scaffold subunits remain undefined. Here, we characterize the functional [...] Read more.
The Spt-Ada-Gcn5 acetyltransferase (SAGA) complex is a conserved transcriptional coactivator that coordinates histone modifications and transcriptional regulation in eukaryotes. In Cryptococcus neoformans, SAGA governs key virulence traits, yet the roles of several core scaffold subunits remain undefined. Here, we characterize the functional roles of Spt7, a core SAGA component, in C. neoformans. Comparative genomics revealed that C. neoformans Spt7 retains conserved histone fold and bromodomain motifs. Deletion of SPT7 produced pleiotropic phenotypes, including defective melanization and capsule formation, impaired titan cell development, and heightened sensitivity to thermal, metal, antifungal, and cell wall stresses. The spt7Δ mutant exhibited strong sensitivity to the echinocandin micafungin, implicating Spt7 in maintaining cell wall integrity. The spt7Δ mutant was avirulent in a murine inhalation model. At the chromatin level, SPT7 deletion disrupted SAGA-dependent histone post-translational modifications, increasing H2B ubiquitination while reducing H3K14ac and H3K18ac levels. Proteomic profiling revealed reduced abundance of ribosomal, mitochondrial, and translational proteins and upregulation of lipid metabolic and secretory pathway components. Collectively, our findings establish Spt7 as a central integrator of SAGA-mediated chromatin regulation, proteomic balance, and virulence in C. neoformans and highlight the SAGA core as a potential antifungal target. Full article
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