The Human Gut Microbiota in Health and Disease

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Gut Microbiota".

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 2942

Special Issue Editors


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Guest Editor
1. Department of Cell Biology and Cancer Science, Rappaport Faculty of Medicine, Technion – Israel Institute of Technology, Technion Integrated Cancer Center (TICC), Haifa 3525433, Israel
2. Canadian Institute for Advanced Research (CIFAR) Azrieli Global Scholar, MaRs Centre, Toronto, ON M5G 1M1, Canada
Interests: microbiome; immune system; systems biology; microbiology; imaging; bacteriophages

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Co-Guest Editor
Department of Cell Biology and Cancer Science, Rappaport Faculty of Medicine, Technion – Israel Institute of Technology, Technion Integrated Cancer Center (TICC), Haifa 3525433, Israel
Interests: microbiome; antibiotic resistance; infectious diseases; immune system; probiotics; prebiotics

Special Issue Information

Dear Colleagues,

The human microbiota is defined as a set of organisms residing within and outside the human body. It consists of bacteria, viruses, archaea, and eukaryotes. This group of microorganisms colonize various sites on and in the human body and interact at intra- and inter-kingdom levels. These interactions play an important role in health and disease. The structural and functional contribution of the gut microbiota to health and disease is constantly evolving in response to host factors such as diet, lifestyle, age, inherited genes, hormonal changes, pH, oxygen conditions, etc. Facultative anaerobes are mainly dominant in the gastrointestinal tract, while strict aerobes inhabit the respiratory tract, nasal cavity, and skin surface. An altered microbiome profile can lead to life-threatening diseases such as cancer, autoimmunity, obesity, bacterial infections, cardiovascular, metabolic, and inflammatory bowel diseases, etc. It is very important to understand the structural and functional contribution of microbial ecosystems and individual species to health and disease.

In this Special Issue of Microorganisms, we will present studies on the role of the human microbiota (bacteria, viruses, archaea, and eukaryotes) in health and disease. Basic (e.g., microbial characterization in vitro, in vivo, ex vivo) and translational science studies (therapeutic and diagnostic potential of the microbiota) are welcome.

Dr. Naama Geva-Zatorsky
Guest Editor
Dr. Neerupma Bhardwaj
Co-Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microbiome
  • immune system
  • systems biology
  • microbiology
  • imaging
  • bacteriophages

Published Papers (1 paper)

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Research

10 pages, 1021 KiB  
Communication
Polyclonal Aptamers for Specific Fluorescence Labeling and Quantification of the Health Relevant Human Gut Bacterium Parabacteroides distasonis
by Hu Xing, Ann-Kathrin Kissmann, Heinz Fabian Raber, Markus Krämer, Valerie Amann, Kathrin Kohn, Tanja Weil and Frank Rosenau
Microorganisms 2021, 9(11), 2284; https://doi.org/10.3390/microorganisms9112284 - 2 Nov 2021
Cited by 7 | Viewed by 2338
Abstract
Single-stranded DNA aptamers as affinity molecules for the rapid, reliable detection of intestinal bacteria are of particular interest to equip health systems with novel robust and cheap diagnostic tools for monitoring the success of supplementation strategies with selected probiotic gut bacteria in the [...] Read more.
Single-stranded DNA aptamers as affinity molecules for the rapid, reliable detection of intestinal bacteria are of particular interest to equip health systems with novel robust and cheap diagnostic tools for monitoring the success of supplementation strategies with selected probiotic gut bacteria in the fight against major widespread threats, such as obesity and neurodegenerative diseases. The human gut bacterium Parabacteroides distasonis (P. distasonis) is positively associated with diseases such as obesity, non-alcoholic fatty liver disease and multiple sclerosis with reduced cell counts in these diseases and is thus a promising potential probiotic bacterium for future microbial supplementation. In this paper we report on the evolution of a specific polyclonal aptamer library by the fluorescence based FluCell-SELEX directed against whole cells of P. distasonis that specifically and efficiently binds and labels P. distasonis. The aptamer library showed high binding affinity and was suited to quantitatively discriminate P. distasonis from other prominent gut bacteria also in mixtures. We believe that this library against a promising probiotic bacterium as a prototype may open new routes towards the development of novel biosensors for the easy and efficient quantitative monitoring of microbial abundance in human microbiomes in general. Full article
(This article belongs to the Special Issue The Human Gut Microbiota in Health and Disease)
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