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Microorganisms
Special Issues
Molecular Biology of Candida albicans
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Molecular Biology of Candida albicans

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Molecular Microbiology and Immunology".

Deadline for manuscript submissions: closed (31 August 2021) | Viewed by 3093

Special Issue Editor

Dr. Rebeca Alonso-Monge

E-Mail Website
Guest Editor
Departamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain
Interests: Candida albicans; response to stress; signaling; commensalism; genetic tools development

Special Issue Information

Dear colleagues,

Candida albicans remains the main fungal pathogen of humans around the world. This commensal fungus is responsible for pathologies ranging from superficial mucosal infections to severe systemic candidemia. These infections predominantly share an endogenous origin, since the precise percentage of C. albicans commensal inhabitation in the human population remains unknown.

Much effort has been devoted toward understanding the role of C. albicans as a pathogen. Virulence models have been implemented and diverse virulence factors have been identified and characterized. The development of genetic tools has allowed for the genetic manipulation of this organism and the analysis of the role of many relevant virulence factors at a molecular level. Currently, different groups have focused their research toward investigating the commensal state of this fungus. Although C. albicans belongs to the human microbiota and cohabits with us from the birth to old age, many questions about Candida–host interactions remain unanswered.

The aim of this Special Issue is to update on the knowledge and advances related to C. albicans and provide a platform for researchers to share their latest results. We cordially invite you to submit research articles, review articles, and short communications related to different aspect of Candida albicans physiology: pathogenesis, commensal state, fungus–host interactions, diagnostic procedures, detection of antifungal resistance, etc.

Dr. Rebeca Alonso-Monge
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Candida albicans
  • Candida spp.
  • biofilms
  • commensalism
  • antifungals and resistance to antifungals
  • Candida–host interaction
  • immune response
  • virulence factors
  • pathogenesis
  • diagnostic methods
  • genetic tools
  • response to stress
  • experimental models

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Published Papers (1 paper)

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Research

14 pages, 14439 KiB  
Article
The Fungicidal Action of Micafungin is Independent on Both Oxidative Stress Generation and HOG Pathway Signaling in Candida albicans
by Rebeca Alonso-Monge, José P. Guirao-Abad, Ruth Sánchez-Fresneda, Jesús Pla, Genoveva Yagüe and Juan Carlos Argüelles
Microorganisms 2020, 8(12), 1867; https://doi.org/10.3390/microorganisms8121867 - 26 Nov 2020
Cited by 11 | Viewed by 2430
Abstract
In fungi, the Mitogen-Activated Protein kinase (MAPK) pathways sense a wide variety of environmental stimuli, leading to cell adaptation and survival. The HOG pathway plays an essential role in the pathobiology of Candida albicans, including the colonization of the gastrointestinal tract in [...] Read more.
In fungi, the Mitogen-Activated Protein kinase (MAPK) pathways sense a wide variety of environmental stimuli, leading to cell adaptation and survival. The HOG pathway plays an essential role in the pathobiology of Candida albicans, including the colonization of the gastrointestinal tract in a mouse model, virulence, and response to stress. Here, we examined the role of Hog1 in the C. albicans response to the clinically relevant antifungal Micafungin (MF), whose minimum inhibitory concentration (MIC) was identical in the parental strain (RM100) and in the isogenic homozygous mutant hog1 (0.016 mg/L). The cell viability was impaired without significant differences between the parental strain, the isogenic hog1 mutant, and the Hog1+ reintegrant. This phenotype was quite similar in a collection of hog1 mutants constructed in a different C. albicans background. MF-treated cells failed to induce a relevant increase of both reactive oxygen species (ROS) formation and activation of the mitochondrial membrane potential in parental and hog1 cells. MF was also unable to trigger any significant activation of the genes coding for the antioxidant activities catalase (CAT1) and superoxide dismutase (SOD2), as well as on the corresponding enzymatic activities, whereas a clear induction was observed in the presence of Amphotericin B (AMB), introduced as a positive control of Hog1 signaling. Furthermore, Hog1 was not phosphorylated by the addition of MF, but, notably, this echinocandin caused Mkc1 phosphorylation. Our results strongly suggest that the toxic effect of MF on C. albicans cells is not mediated by the Hog1 MAPK and is independent of the generation of an internal oxidative stress in C. albicans. Full article
(This article belongs to the Special Issue Molecular Biology of Candida albicans)
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