Editorial Board Members' Collection Series: Gut Microbiota and Host Diseases

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Gut Microbiota".

Deadline for manuscript submissions: closed (31 July 2025) | Viewed by 1058

Special Issue Editors


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Guest Editor
Department of Biotechnology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
Interests: gut microbiota; cell host interaction; molecular mechanism; probiotic identification; cultureomics; genetic engineering

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Guest Editor
Centre for Genecology, School of Health and Sport Sciences, University of the Sunshine Coast, Sippy Downs, QLD 4556, Australia
Interests: medical microbiology; infectious disease and pathogenesis
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Special Issue Information

Dear Colleagues,

The gut microbiota plays an important role in a variety of physiological processes such as digestion, immune regulation, and metabolism. Changes in the composition and function of the gut microbiota are closely related to a variety of human diseases, including inflammatory bowel disease (IBD), obesity, diabetes, allergies, and even neurological diseases. A deeper understanding of these associations will help us explore the interaction between gut microorganisms and the host immune system, the impact on nutrient absorption, the production of metabolites, and the regulation of inflammation levels. In addition, studies have shown that regulating the gut microbiome through probiotics, prebiotics, dietary adjustments or fecal microbial transplants (FMT) may become an effective intervention for the treatment or prevention of certain diseases. Further exploration of the interaction mechanism between the gut microbiota and the host will reveal new insights into the pathogenesis of diseases and lay the foundation for the development of personalized microbiome medical methods.

Prof. Dr. Zhi Liu
Dr. Mohammad Katouli
Guest Editors

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Keywords

  • gut microbiota
  • human diseases
  • treatment
  • immune regulation

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Published Papers (1 paper)

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Review

19 pages, 478 KB  
Review
The Role of Gut Microbiota and Its Metabolites in Mitigating Radiation Damage
by Hansheng Zhu, Xin Yan, Hao Shi, Yiping Chen, Changyi Huang, Yue Zhou, Shiying Yan, Nan Zhang, Jia Wang, Jian Zhang, Chaoyi Han, Qian Chen, Jian Zhao and Mei Cao
Microorganisms 2025, 13(9), 2151; https://doi.org/10.3390/microorganisms13092151 - 15 Sep 2025
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Abstract
With the widespread use of ionizing radiation (IR) in medical and industrial settings, irradiation has become increasingly common, posing significant risks to human health. Among the various organs affected, the gut is particularly sensitive to radiation-induced damage, leading to conditions such as radiation-induced [...] Read more.
With the widespread use of ionizing radiation (IR) in medical and industrial settings, irradiation has become increasingly common, posing significant risks to human health. Among the various organs affected, the gut is particularly sensitive to radiation-induced damage, leading to conditions such as radiation-induced intestinal damage (RIID). Recent studies have emphasized the critical role of gut microbiota and its metabolites in mitigating radiation-induced injury. This review discusses the effects of IR on the mammalian and human gut microbiota. We examine the dynamics of gut microbiota composition during and after irradiation, and emphasize the protective role of the gut flora and the metabolites in the pathophysiological mechanisms exhibited during radiation injury. In addition, this article investigates how specific metabolites, such as short-chain fatty acids and indole derivatives, may contribute to the mitigation of inflammation and promotion of gut barrier integrity. In addition, various therapeutic strategies based on modulating the gut microbiota, such as probiotics, antibiotics, and fecal microbiota transplantation, are discussed to understand their potential to prevent or mitigate RIID. Understanding the interactions between IR, gut microbiota and their metabolites provides new avenues for developing innovative therapeutic approaches to improve patient outcomes during and after radiotherapy. Future research directions could focus on optimizing microbiota-based therapies and exploring the role of diet and lifestyle in enhancing intestinal health during irradiation. Full article
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