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Microorganisms
Special Issues
Diagnosis, Characterization and Treatment of Emerging Pathogens, Third Edition
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Diagnosis, Characterization and Treatment of Emerging Pathogens, Third Edition

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Public Health Microbiology".

Deadline for manuscript submissions: 31 March 2026 | Viewed by 801

Special Issue Editor

Dr. Shengxi Chen

E-Mail Website
Guest Editor
Biodesign Center for Bioenergetics, Arizona State University, Tempe, AZ 85281, USA
Interests: cancers; viral infection; emerging pathogens; diagnosis; treatment
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is a continuation of our previous Special Issues, entitled “Diagnosis, Characterization and Treatment of Emerging Pathogens and Diagnosis, Characterization and Treatment of Emerging Pathogens, Second Edition”.

Emerging infectious diseases are perhaps the most rapidly spreading diseases. SARS-CoV-2 has infected 556 million people and caused more than 6 million deaths worldwide. To date, the effects of this virus are still resonating worldwide. Recently, the monkeypox virus emerged and spread to more than 30 countries over the course of about one month. Concurrently, many other pathogens have emerged, including malaria, Zika virus, dengue, Ebola, West Nile virus, and diarrheagenic E. coli, all of which threaten the health of billions of people worldwide. To help in the fight against these emerging infectious diseases, we aim to collect manuscripts focusing on emerging pathogens, including viruses, bacteria, protozoa, and fungi. 

The areas of interest could include, but are not limited to, the following:

  • Novel methods and strategies for the early detection of emerging pathogens;
  • The characterization of specific genes or protein targets for the detection or treatment of emerging pathogens;
  • Novel agents to inhibit emerging pathogens.

Dr. Shengxi Chen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • emerging pathogens
  • detection
  • characterization treatment
  • infectious diseases
  • viruses
  • bacteria
  • protozoa
  • fungi

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

11 pages, 247 KB  
Article
Risk Factors for Severe Outcomes Among Pediatric Cancer Patients with Respiratory Viral Infection
by Alon Kristal, Avi Magid, Nira Arad-Cohen, Moran Szwarcwort-Cohen and Yael Shachor-Meyouhas
Microorganisms 2025, 13(11), 2628; https://doi.org/10.3390/microorganisms13112628 - 19 Nov 2025
Cited by 1 | Viewed by 628
Abstract
Viral respiratory infections pose a significant risk for pediatric cancer patients and may lead to a delay in chemotherapy, prolonged hospitalization, and mortality. Limited data exist regarding the contributors to adverse clinical outcomes. The present study aims to describe the associations between clinical, [...] Read more.
Viral respiratory infections pose a significant risk for pediatric cancer patients and may lead to a delay in chemotherapy, prolonged hospitalization, and mortality. Limited data exist regarding the contributors to adverse clinical outcomes. The present study aims to describe the associations between clinical, epidemiological, and laboratory factors and severe outcomes of respiratory viral infections among children with cancer. This was a retrospective cohort study among pediatric cancer patients treated in the Pediatric Hematology–Oncology Department at Rambam Health Care Campus from 2016 to 2022. Patients with a positive rt-qPCR test for one of the following viruses were included: Adenovirus, Respiratory Syncytial Virus (RSV), Human Metapneumovirus (HMPV), SARS-CoV-2, Parainfluenza, or Influenza. Demographic, clinical, and laboratory data were collected for each case. GEE analyses were conducted to assess the associations between independent variables and severe outcomes (admission to the Pediatric Intensive Care Unit (PICU), hospitalizations exceeding seven days, co-bacterial infections, and mortality within 30 days). A total of 366 viral infections episodes were identified among 238 patients. There were 187 (51%) children with hematological malignancies, 113 (31%) with solid tumors, and 66 patients (18%) who had undergone bone marrow transplantation. Influenza was the most frequently detected virus, accounting for 89 events (24%), followed closely by Adenovirus, with 82 events (23%). Among the 38 severe events, prolonged hospitalization was the most prevalent outcome, occurring in 33 cases. Adenovirus infection was significantly associated with severe outcomes (OR = 2.97, p = 0.010), and antibiotic therapy was associated with 3.62 times higher odds of severe outcomes (p = 0.010). Patients presenting with O2 saturation levels below 92% had 5.71 times higher odds of experiencing severe outcomes. Among the subgroup of hematological malignancies, RSV was positively associated with severe outcomes (OR = 4.08, p = 0.048). Adenovirus was associated with severe outcomes in pediatric cancer patients, highlighting its prevalence and potential for treatment. Similarly, RSV was associated with adverse outcomes specifically among hematological cancer patients, emphasizing the importance of vaccination. A very low mortality from viral infection was also notable. Full article
(This article belongs to the Special Issue Diagnosis, Characterization and Treatment of Emerging Pathogens, Third Edition)
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