HIV-Associated Neurocognitive Disorders: Mechanisms, Models, and Emerging Therapeutic Frontiers
A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Medical Microbiology".
Deadline for manuscript submissions: 31 May 2026 | Viewed by 23
Special Issue Editor
Special Issue Information
Dear Colleagues,
Despite remarkable progress in antiretroviral therapy (ART), HIV infection remains a global health challenge, particularly due to persistent viral reservoirs, chronic inflammation, and neurological complications collectively known as HIV-associated neurocognitive disorders (HANDs). This Special Issue will provide a comprehensive platform for original research articles and reviews that enhance our understanding of HIV pathogenesis, immune dysregulation, and host–virus interactions across diverse tissues and cell types.
We particularly encourage contributions exploring molecular and cellular mechanisms driving neuroinflammation, blood–brain barrier dysfunction, and neuronal injury in HIV infection. Studies integrating omics technologies, single-cell approaches, and advanced in vitro or in vivo models to unravel the role of astrocytes, microglia, and neuronal networks in HANDs are highly welcome. Furthermore, we invite submissions on emerging therapeutic strategies, including nanomedicine, immunomodulation, and gene editing, to address viral persistence and neurodegeneration.
By bringing together cutting-edge research from across virology, immunology, and neurobiology, this Special Issue will advance our translational understanding of HIV infection and foster the development of innovative interventions aimed at achieving functional cure and improving long-term neurological outcomes.
Dr. Hina Singh
Guest Editor
Manuscript Submission Information
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Keywords
- neuroinflammation
- HIV-associated neurocognitive disorders (HANDs)
- host–virus interactions
- astrocyte–microglia crosstalk
- viral reservoirs
- neurodegeneration
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