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Microorganisms
Special Issues
The Role of Heat Shock Proteins in Diseases and Their...
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The Role of Heat Shock Proteins in Diseases and Their Therapeutic Potential: Environmental Stress and Microorganisms

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Molecular Microbiology and Immunology".

Deadline for manuscript submissions: closed (15 July 2024) | Viewed by 8060

Special Issue Editors

Prof. Dr. Xiaohua Teng

E-Mail Website
Guest Editor
College of Animal Science and Technology, Northeast Agricultural University, Harbin, China
Interests: environmental pollutants; toxicology; molecular mechanism
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. You Tang

E-Mail Website1 Website2
Co-Guest Editor
Digital Agriculture Key Discipline of Jilin Province, Jilin Agricultural Science and Technology University, Jilin, China
Interests: heat shock proteins; environmental pollutants; diseases; therapy; molecular mechanism; toxicology

Special Issue Information

Dear Colleagues,

We are happy to announce this Special Issue of Microorganisms on "The role of Heat Shock Proteins in Diseases and Their Therapeutic Potential: Environmental stress and Microorganisms”. Microorganisms (ISSN: 2076-2607, IF 4.926) is an international, peer-reviewed open access journal related to prokaryotic and eukaryotic microorganisms, viruses, as well as prions.

Heat shock proteins (HSPs), a family of highly conserved proteins that that bind and help fold nascent or denatured polypeptides, ubiquitously exist in organisms (from bacteria to mammals). HSPs, also known as stress proteins, can change in case of disease occurrence and in the presence of environmental stressors such as microorganisms. Recent reports indicated that microorganisms played important role in the mechanism of biological injury induced by environmental stress.

In this Special Issue, our aim is to provide an in-depth view of "The Role of Heat Shock Proteins in Diseases and Their Therapeutic Potential: Environmental Stress including Biological Stress and Abiotic Stress and Microorganisms”. We welcome high-quality original research and review articles focusing on (but not limited to) the following subtopics:

  • Microorganisms
  • Heat Shock Proteins
  • Environmental stress
  • Diseases  
  • Therapy
  • Molecular mechanism
  • Environmental stress

Prof. Dr. Xiaohua Teng
Prof. Dr. You Tang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microorganisms
  • heat shock proteins
  • environmental stress
  • diseases
  • therapy
  • molecular mechanism
  • microorganisms

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Published Papers (2 papers)

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Review

25 pages, 3772 KiB  
Review
Insights and Perspectives on the Role of Proteostasis and Heat Shock Proteins in Fungal Infections
by João Neves-da-Rocha, Maria J. Santos-Saboya, Marcos E. R. Lopes, Antonio Rossi and Nilce M. Martinez-Rossi
Microorganisms 2023, 11(8), 1878; https://doi.org/10.3390/microorganisms11081878 - 25 Jul 2023
Cited by 8 | Viewed by 4551
Abstract
Fungi are a diverse group of eukaryotic organisms that infect humans, animals, and plants. To successfully colonize their hosts, pathogenic fungi must continuously adapt to the host’s unique environment, e.g., changes in temperature, pH, and nutrient availability. Appropriate protein folding, assembly, and degradation [...] Read more.
Fungi are a diverse group of eukaryotic organisms that infect humans, animals, and plants. To successfully colonize their hosts, pathogenic fungi must continuously adapt to the host’s unique environment, e.g., changes in temperature, pH, and nutrient availability. Appropriate protein folding, assembly, and degradation are essential for maintaining cellular homeostasis and survival under stressful conditions. Therefore, the regulation of proteostasis is crucial for fungal pathogenesis. The heat shock response (HSR) is one of the most important cellular mechanisms for maintaining proteostasis. It is activated by various stresses and regulates the activity of heat shock proteins (HSPs). As molecular chaperones, HSPs participate in the proteostatic network to control cellular protein levels by affecting their conformation, location, and degradation. In recent years, a growing body of evidence has highlighted the crucial yet understudied role of stress response circuits in fungal infections. This review explores the role of protein homeostasis and HSPs in fungal pathogenicity, including their contributions to virulence and host–pathogen interactions, as well as the concerted effects between HSPs and the main proteostasis circuits in the cell. Furthermore, we discuss perspectives in the field and the potential for targeting the components of these circuits to develop novel antifungal therapies. Full article
(This article belongs to the Special Issue The Role of Heat Shock Proteins in Diseases and Their Therapeutic Potential: Environmental Stress and Microorganisms)
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17 pages, 627 KiB  
Review
New Insights into the Role and Therapeutic Potential of Heat Shock Protein 70 in Bovine Viral Diarrhea Virus Infection
by Nannan Chen, Tongtong Bai, Shuang Wang, Huan Wang, Yue Wu, Yu Liu and Zhanbo Zhu
Microorganisms 2023, 11(6), 1473; https://doi.org/10.3390/microorganisms11061473 - 1 Jun 2023
Cited by 2 | Viewed by 2690
Abstract
Bovine viral diarrhea virus (BVDV), a positive-strand RNA virus of the genus Pestivirus in the Flaviviridae family, is the causative agent of bovine viral diarrhea–mucosal disease (BVD-MD). BVDV’s unique virion structure, genome, and replication mechanism in the Flaviviridae family render it a useful [...] Read more.
Bovine viral diarrhea virus (BVDV), a positive-strand RNA virus of the genus Pestivirus in the Flaviviridae family, is the causative agent of bovine viral diarrhea–mucosal disease (BVD-MD). BVDV’s unique virion structure, genome, and replication mechanism in the Flaviviridae family render it a useful alternative model for evaluating the effectiveness of antiviral drugs used against the hepatitis C virus (HCV). As one of the most abundant and typical heat shock proteins, HSP70 plays an important role in viral infection caused by the family Flaviviridae and is considered a logical target of viral regulation in the context of immune escape. However, the mechanism of HSP70 in BVDV infection and the latest insights have not been reported in sufficient detail. In this review, we focus on the role and mechanisms of HSP70 in BVDV-infected animals/cells to further explore the possibility of targeting this protein for antiviral therapy during viral infection. Full article
(This article belongs to the Special Issue The Role of Heat Shock Proteins in Diseases and Their Therapeutic Potential: Environmental Stress and Microorganisms)
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