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Microorganisms
Special Issues
Foodborne Bacteria–Host Interactions: 2nd Edition
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Foodborne Bacteria–Host Interactions: 2nd Edition

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Food Microbiology".

Deadline for manuscript submissions: closed (15 February 2025) | Viewed by 9730

Special Issue Editors

Dr. Anja Klančnik

E-Mail Website1 Website2
Guest Editor
Department of Food Microbiology, Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia
Interests: campylobacter jejuni; bacterial stress response; host-pathogen interactions; antibacterial resistance mechanism; biofilm-specific resistant phenotype; virulence factors; bacterial communication
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Maja Abram

E-Mail Website
Guest Editor
Department of Microbiology and Parasitology, Faculty of Medicine, and Clinical Hospital Centre Rijeka, University of Rijeka, Rijeka, Croatia
Interests: listeria; campylobacter; pathogenesis; infection; antibacterial resistance; immune response
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is a continuation of our 2022 Special Issue "Foodborne Bacteria–Host Interactions" (https://www.mdpi.com/journal/microorganisms/special_issues/Foodborne_Bacteria).

Foodborne diseases can be highlighted as one of the most important health problems in recent decades. Food contamination can occur at any stage of the farm-to-consumer continuum from environmental, animal, or human sources, causing foodborne illnesses that are a global public health problem and affect an estimated 600 million people annually. Pathogen–host interaction addresses the understanding of (i) host–species interaction with insights into molecular pathogenesis, the evolution of pathogenic microbes, and the potential of pathogens to cross the species barrier to infect new hosts; and (ii) mechanisms by which pathogenic bacteria communicate with other microorganisms and interact with the host, which is critical for the application of innovative control strategies.

As Guest Editors of this Special Issue, we invite you to submit research articles, review articles, and short communications related to foodborne bacteria–host interactions, in particular, regarding topics such as pathogenesis, virulence factors, physiology, gene regulation, and immune response.

Dr. Anja Klančnik
Prof. Dr. Maja Abram
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • foodborne bacteria
  • pathogen–host interactions
  • pathogenesis
  • virulence factors
  • bacterial communication
  • infection

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Published Papers (4 papers)

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Research

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14 pages, 4972 KiB  
Article
Comparative Genomic Profiles of Salmonella Typhimurium and Salmonella Dublin Bovine Isolates from the U.S. Indicate Possible Factors Associated with the Host Adaptation of Salmonella Dublin in the Region
by Kingsley E. Bentum, Emmanuel Kuufire, Rejoice Nyarku, Viona Osei, Benjamin Adu-Addai, Jonathan G. Frye, Charlene R. Jackson, Temesgen Samuel and Woubit Abebe
Microorganisms 2025, 13(4), 886; https://doi.org/10.3390/microorganisms13040886 - 12 Apr 2025
Viewed by 594
Abstract
Salmonella Dublin (S. Dublin) and Salmonella Typhimurium (S. Typhimurium) are commonly linked to bovine salmonellosis. S. Dublin is, however, considered a bovine-adapted serovar for primarily infecting and thriving in cattle. Using S. Typhimurium (a generalist serovar) as a benchmark, this study [...] Read more.
Salmonella Dublin (S. Dublin) and Salmonella Typhimurium (S. Typhimurium) are commonly linked to bovine salmonellosis. S. Dublin is, however, considered a bovine-adapted serovar for primarily infecting and thriving in cattle. Using S. Typhimurium (a generalist serovar) as a benchmark, this study investigates genomic factors contributing to S. Dublin’s adaptation to cattle hosts in the U.S. A total of 1337 S. Dublin and 787 S. Typhimurium whole-genome sequences from bovine sources were analyzed with CARD (version 4.0.0), ARG-NOTT (version 6), and AMRfinderPlus (version 4.0.3) for antimicrobial resistance (AMR) genes; VFDB and AMRfinderPlus for virulence genes; AMRFinderPlus for stress genes; and Plasmidfinder for plasmids. Existing clonal groups among isolates of the two serovars were also investigated using the Hierarchical Clustering of Core Genome Multi-Locus Sequence Typing (HierCC-cgMLST) model. The results revealed minimal genomic variation among S. Dublin isolates. Comparatively, the IncX1 plasmid was somewhat exclusively identified in S. Dublin isolates and each carried an average of four plasmids (p-value < 0.05). Furthermore, S. Dublin isolates exhibited a higher prevalence of AMR genes against key antimicrobials, including aminoglycosides, beta-lactams, tetracyclines, and sulfonamides, commonly used in U.S. cattle production. Additionally, Type VI secretion system genes tssJKLM and hcp2/tssD2, essential for colonization, were found exclusively in S. Dublin isolates with over 50% of these isolates possessing genes that confer resistance to heavy metal stressors, like mercury. These findings suggest that S. Dublin’s adaptation to bovine hosts in the U.S. is supported by a conserved genetic makeup enriched with AMR genes, virulence factors, and stress-related genes, enabling it to colonize and persist in the bovine gut. Full article
(This article belongs to the Special Issue Foodborne Bacteria–Host Interactions: 2nd Edition)
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25 pages, 6449 KiB  
Article
Multi-Omics of Campylobacter jejuni Growth in Chicken Exudate Reveals Molecular Remodelling Associated with Altered Virulence and Survival Phenotypes
by Lok Man, Pamela X. Y. Soh, Tess E. McEnearney, Joel A. Cain, Ashleigh L. Dale and Stuart J. Cordwell
Microorganisms 2024, 12(5), 860; https://doi.org/10.3390/microorganisms12050860 - 25 Apr 2024
Cited by 1 | Viewed by 1733
Abstract
Campylobacter jejuni is the leading cause of foodborne human gastroenteritis in the developed world. Infections are largely acquired from poultry produced for human consumption and poor food handling is thus a major risk factor. Chicken exudate (CE) is a liquid produced from defrosted [...] Read more.
Campylobacter jejuni is the leading cause of foodborne human gastroenteritis in the developed world. Infections are largely acquired from poultry produced for human consumption and poor food handling is thus a major risk factor. Chicken exudate (CE) is a liquid produced from defrosted commercial chicken products that facilitates C. jejuni growth. We examined the response of C. jejuni to growth in CE using a multi-omics approach. Changes in the C. jejuni proteome were assessed by label-based liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). We quantified 1328 and 1304 proteins, respectively, in experiments comparing 5% CE in Mueller–Hinton (MH) medium and 100% CE with MH-only controls. These proteins represent 81.8% and 80.3% of the predicted C. jejuni NCTC11168 proteome. Growth in CE induced profound remodelling of the proteome. These changes were typically conserved between 5% and 100% CE, with a greater magnitude of change observed in 100% CE. We confirmed that CE induced C. jejuni biofilm formation, as well as increasing motility and resistance against oxidative stress, consistent with changes to proteins representing those functions. Assessment of the C. jejuni metabolome showed CE also led to increased intracellular abundances of serine, proline, and lactate that were correlated with the elevated abundances of their respective transporters. Analysis of carbon source uptake showed prolonged culture supernatant retention of proline and succinate in CE-supplemented medium. Metabolomics data provided preliminary evidence for the uptake of chicken-meat-associated dipeptides. C. jejuni exposed to CE showed increased resistance to several antibiotics, including polymyxin B, consistent with changes to tripartite efflux system proteins and those involved in the synthesis of lipid A. The C. jejuni CE proteome was also characterised by very large increases in proteins associated with iron acquisition, while a decrease in proteins containing iron–sulphur clusters was also observed. Our data suggest CE is both oxygen- and iron-limiting and provide evidence of factors required for phenotypic remodelling to enable C. jejuni survival on poultry products. Full article
(This article belongs to the Special Issue Foodborne Bacteria–Host Interactions: 2nd Edition)
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17 pages, 3960 KiB  
Article
Intestinal Colonization of Campylobacter jejuni and Its Hepatic Dissemination Are Associated with Local and Systemic Immune Responses in Broiler Chickens
by Sophie Chagneau, Marie-Lou Gaucher, Philippe Fravalo, William P. Thériault and Alexandre Thibodeau
Microorganisms 2023, 11(7), 1677; https://doi.org/10.3390/microorganisms11071677 - 28 Jun 2023
Cited by 4 | Viewed by 1971
Abstract
Campylobacter jejuni is an important foodborne pathogen. Despite the lack of clinical signs associated with its colonization in poultry, it has been reported to interact with the intestinal immune system. However, little is known about the interaction between C. jejuni and the chicken [...] Read more.
Campylobacter jejuni is an important foodborne pathogen. Despite the lack of clinical signs associated with its colonization in poultry, it has been reported to interact with the intestinal immune system. However, little is known about the interaction between C. jejuni and the chicken immune system, especially in the context of hepatic dissemination. Therefore, to follow up on our previous study showing intestinal colonization and hepatic spread of C. jejuni, cecal tonsils and liver samples were collected from these birds to determine the mRNA levels of chemokines and cytokines. Serum samples were also collected to determine serum amyloid A (SAA) concentrations and specific IgY titers. Lack of Th17 induction was observed in the cecal tonsils of only the liver-contaminated groups. This hepatic dissemination was accompanied by innate, Th1 and Th2 immune responses in livers, as well as an increase in SAA concentrations and specific IgY levels in sera. Campylobacter appears to be able to restrain the induction of the chicken gut immunity in particular conditions, possibly enhancing its hepatic dissemination and thus eliciting systemic immune responses. Although Campylobacter is often recognized as a commensal-like bacterium in chickens, it seems to modulate the gut immune system and induce systemic immunity. Full article
(This article belongs to the Special Issue Foodborne Bacteria–Host Interactions: 2nd Edition)
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Review

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15 pages, 907 KiB  
Review
Host–Pathogen Interactions during Shiga Toxin-Producing Escherichia coli Adherence and Colonization in the Bovine Gut: A Comprehensive Review
by Lekshmi K. Edison, Indira T. Kudva and Subhashinie Kariyawasam
Microorganisms 2024, 12(10), 2009; https://doi.org/10.3390/microorganisms12102009 - 3 Oct 2024
Viewed by 1380
Abstract
Shiga toxin-producing Escherichia coli (STEC) is a significant public health threat due to its ability to cause severe gastrointestinal diseases in humans, ranging from diarrhea to life-threatening conditions such as hemorrhagic colitis and hemolytic uremic syndrome (HUS). As the primary reservoir of STEC, [...] Read more.
Shiga toxin-producing Escherichia coli (STEC) is a significant public health threat due to its ability to cause severe gastrointestinal diseases in humans, ranging from diarrhea to life-threatening conditions such as hemorrhagic colitis and hemolytic uremic syndrome (HUS). As the primary reservoir of STEC, cattle play a crucial role in its transmission through contaminated food and water, posing a considerable risk to human health. This comprehensive review explores host–pathogen interactions during STEC colonization of the bovine gut, focusing on the role of gut microbiota in modulating these interactions and influencing disease outcomes. We integrated findings from published transcriptomics, proteomics, and genomics studies to provide a thorough understanding of how STEC adheres to and colonizes the bovine gastrointestinal tract. The insights from this review offer potential avenues for the development of novel preventative and therapeutic strategies aimed at controlling STEC colonization in cattle, thereby reducing the risk of zoonotic transmission. Full article
(This article belongs to the Special Issue Foodborne Bacteria–Host Interactions: 2nd Edition)
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