Medically Important Microbial Proteins

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Molecular Microbiology and Immunology".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 1670

Special Issue Editors


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Guest Editor
Department of Protein Engineering and Biochemistry, Institute of Virology, Vaccines and Sera, Torlak, 11152 Belgrade, Serbia
Interests: hospital; immune

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Guest Editor Assistant
Department of Immunology and Preclinical Testing, Institute of Virology, Vaccines and Sera, Torlak, 11152 Belgrade, Serbia
Interests: inflammatory bowel diseases; mechanisms of innate immune response; interactions between the microbiome and the immune system; trained immunity

Special Issue Information

Dear Colleagues,

Causation can be determined for many natural phenomena, with the major purpose of the immune system undoubtedly being to fight microbial infections. The variability, redundance, memory, specificity, pan reactivity and synergism of the immune system enable it to fight off almost any microbe. Yet, the constant arms race in the evolution of both microbes and the mammalian immune system creates a vast undiscovered spectrum of interesting interactions developing between the two—an evolutionary cat and mouse game fought at the molecular level.

This Special Issue focuses on microbial proteins that interact with the immune system, irrespective of the type of microorganism or the type of interaction.

Precedence will be given to proteins from medically important microorganisms, such as ESKAPE pathogens, but also all prospective protein vaccine antigens and drug targets. Research about proteins that have a significant influence on the components of the immune system, through specific interactions, by inhibiting the immune response are also welcome.

As the body of knowledge regarding medically important microbial proteins is vast, review articles, meta-analyses and opinions are welcome; however, original research papers will be prioritized.

Dr. Rajna Minić
Guest Editors

Dr. Veljko Blagojević
Guest Editor Assistant

Manuscript Submission Information

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Keywords

  • immune system interactions
  • microbial proteins
  • ESKAPE pathogens

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Published Papers (1 paper)

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Research

15 pages, 3016 KiB  
Article
Bactericidal/Permeability-Increasing Protein (BPI), a Novel Antimicrobial Molecule in Human Breast Milk with Immune Potential
by Alba Soledad Aquino-Domínguez, María de los Ángeles Romero-Tlalolini, Honorio Torres-Aguilar, Juan Carlos Rodríguez-Alba, Lucia Lourdes Martínez-Martínez, Francisco Javier Sánchez-Peña, María Teresa Hernández-Huerta, Jesús Elizarrarás-Rivas, Gabriela Tapia-Pastrana, Melisa Gómez-López, Elsa Cruz-Martínez, Uriel Eleazar Hernández-Corrales and Sergio Roberto Aguilar-Ruiz
Microorganisms 2025, 13(1), 115; https://doi.org/10.3390/microorganisms13010115 - 8 Jan 2025
Viewed by 1202
Abstract
Breast milk is a fluid of vital importance during the first stages of life of the newborn since, in addition to providing nutrients, it also contains cells and molecules of the immune system, which protect the neonate from infection and, at the same [...] Read more.
Breast milk is a fluid of vital importance during the first stages of life of the newborn since, in addition to providing nutrients, it also contains cells and molecules of the immune system, which protect the neonate from infection and, at the same time, modulate the establishment of the microbiota. Bactericidal/permeability-increasing protein (BPI) is relevant in preventing disease and sepsis in neonates. Therefore, the following work aimed to demonstrate the presence of BPI in the different stages of breast milk and its possible immune functions. Our results demonstrate for the first time the presence of soluble BPI and leukocytes and epithelial cells containing it, primarily in the colostrum stage. Using BPI at concentrations typical of colostrum, we observed that it reduces the growth of two distinct E. coli strains, enhances the uptake of these bacteria by monocytes, and suppresses the secretion of the proinflammatory cytokine interleukin (IL)-8 in infected intestinal cells. These findings suggest that BPI transferred via colostrum from mother to newborn may play a significant role in providing antimicrobial and anti-inflammatory protection during the early stages of life. Full article
(This article belongs to the Special Issue Medically Important Microbial Proteins)
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