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Microorganisms
Special Issues
Fungal Infections and Antifungal Agents
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Fungal Infections and Antifungal Agents

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Antimicrobial Agents and Resistance".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 1816

Special Issue Editor

Dr. Stefanie Bressan Waller

E-Mail Website
Guest Editor
Department of Clinical Pathology, Veterinary Mycology Section, Faculty of Veterinary Medicine, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil
Interests: public health; veterinary mycology; zoonosis; sporotrichosis; antifungal therapy; antifungal resistance; natural products; antimicrobial susceptibility testing

Special Issue Information

Dear Colleagues,

Fungal infections represent a growing concern in both human and veterinary medicine, affecting a wide range of hosts and resulting in significant morbidity and mortality. The emergence of resistant strains, coupled with the limited number of effective antifungal agents, underscores the urgent need for new diagnostic and therapeutic approaches. This Special Issue aims to bring together high-quality research, case reports, and reviews that address the epidemiology, pathogenesis, diagnosis, and treatment of fungal infections across different species, including humans. We encourage the submission of works that investigate host–pathogen interactions, resistance mechanisms, the discovery of new antifungal drugs, and innovative therapeutic strategies, such as natural products, drug combinations, and nanotechnology-based systems. Contributions that integrate findings between human and animal health, from a One Health perspective, are particularly welcome. By integrating clinical, laboratory, and field data, this Special Issue seeks to foster a comprehensive understanding of fungal diseases and promote the development of more effective antifungal interventions.

Dr. Stefanie Bressan Waller
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • fungal infections
  • antifungal agents
  • antifungal drug discovery

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Published Papers (2 papers)

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Research

16 pages, 8828 KB  
Article
Fatal Pneumonia Caused by Beauveria bassiana in a Kemp’s Ridley Sea Turtle (Lepidochelys kempii, Garman, 1880) on the Portuguese Coast: Case Report and Review of Beauveria spp. Infections in Reptiles
by Gonçalo N. Marques, Ricardo Lopes, Maria Conceição Peleteiro, Jaqueline T. Bento, João R. Mesquita, Fábio Abade dos Santos, Leonor Delgado, Ana Cláudia Coelho, Miguel Lourenço, Miriam Leal, Virgínia Lopes, Ana Paula Castro, Rita Barny, Joana Guerra, Nuno Urbani, Antonieta Nunes, Yohann Santos, Isabel Gaspar, Andreia Garcês and João Neves
Microorganisms 2025, 13(9), 2092; https://doi.org/10.3390/microorganisms13092092 - 8 Sep 2025
Viewed by 630
Abstract
The Kemp’s ridley sea turtle (Lepidochelys kempii) is the most critically endangered sea turtle species, with a distribution primarily restricted to the Gulf of Mexico. Its occurrence along the Iberian Peninsula is exceedingly rare. This study describes the postmortem findings of [...] Read more.
The Kemp’s ridley sea turtle (Lepidochelys kempii) is the most critically endangered sea turtle species, with a distribution primarily restricted to the Gulf of Mexico. Its occurrence along the Iberian Peninsula is exceedingly rare. This study describes the postmortem findings of a juvenile L. kempii rescued off the Portuguese coast in 2024, which died after 11 days in rehabilitation despite intensive supportive care. Necropsy revealed severe, diffuse pneumonia. Histopathological examination showed interstitial inflammation and branching septate hyphae, while fungal culture and DNA sequencing confirmed the presence of Beauveria bassiana. Mycotic diseases in reptiles are often underrecognised but can lead to significant morbidity and mortality, particularly in immunocompromised or stressed individuals such as stranded marine turtles. This rare occurrence of a L. kempii on the Portuguese coast provides important insights into the species’ dispersal patterns and underlines the potential conservation implications of opportunistic fungal infections in endangered species. Full article
(This article belongs to the Special Issue Fungal Infections and Antifungal Agents)
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13 pages, 1819 KB  
Article
Human-like Biofilm Models to Study the Activity of Antifungals Against Aspergillus fumigatus
by Dan-Tiberiu Furnica, Julia Falkenstein, Silke Dittmer, Joerg Steinmann, Peter-Michael Rath and Lisa Kirchhoff
Microorganisms 2025, 13(9), 2040; https://doi.org/10.3390/microorganisms13092040 - 31 Aug 2025
Viewed by 657
Abstract
Aspergillus fumigatus is an opportunistic filamentous fungus that primarily affects the respiratory tract of the human body. Depending on its host’s immune response, the pathogen can cause invasive pulmonary aspergillosis (IPA). Biofilm formation by A. fumigatus increases virulence and resistance against antifungals and [...] Read more.
Aspergillus fumigatus is an opportunistic filamentous fungus that primarily affects the respiratory tract of the human body. Depending on its host’s immune response, the pathogen can cause invasive pulmonary aspergillosis (IPA). Biofilm formation by A. fumigatus increases virulence and resistance against antifungals and immune response and is one important factor in IPA development. Here, two human-like models, precision cut lung slices (PCLS) and a biofilm co-culture model, have been developed to test the anti-biofilm activity of voriconazole, amphotericin B, as well as luliconazole against A. fumigatus. In both assays, metabolically active A. fumigatus biofilms were examined at different biofilm developmental stages using an XTT assay. A decrease in the metabolic activity of the fungal biofilms was detected for each of the tested agents in both assays. Significant anti-biofilm effects exist against early-stage biofilm in the co-culture model. In the PCLS assay, amphotericin B showed the strongest inhibition after 24 h. In conclusion, the applied PCLS ex vivo model can be used to study the property and activity of certain antifungal compounds against Aspergillus biofilm. With its close resemblance to human conditions, the PCLS model has the potential for improving the current understanding of biofilm treatments in laboratory settings. Full article
(This article belongs to the Special Issue Fungal Infections and Antifungal Agents)
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