Gut Microbiota and Metabolic Disease Pathogenesis

Dear Colleagues,

The gut microbiota, referring to the rich and complex set of microorganisms that reside in the human gastrointestinal tract, has been underestimated as a key player in health and disease. However, in the last decade, a plethora of studies have demonstrated the instrumental involvement of the gut microbiota in the physiological homeostasis of a healthy gut and the pathogenesis of a myriad of diseases. In addition, accumulating evidence suggests that gut microbiota is also a rich source of novel therapeutic targets and may, therefore, aid personalized and precision microbiome therapies. More research is needed to better understand the gut microbiota profile and how its dynamics (structural, morphological, and anatomical changes; eubiosis; and dysbiosis) are affected by host genetics or environmental factors, such as diet, medications, or pollution. Against this background, more can be discovered about the gut microbiota in terms of transcriptomics, proteomics, metabolomics, mitochondrial bioenergetics, metabolism, and signaling. Furthermore, much remains to be elucidated regarding the gut–brain axis, neuroactive microbes, cardio-pulmonary vascular diseases, metabolic diseases, cancer, and immuno-oncology.

Therefore, in this Special Issue, we will focus on research questions that aim to better understand the topics mentioned above. We are pleased to invite your valuable scientific contributions in the form of original research articles or reviews.

We look forward to receiving your contributions.

Dr. Gerald Maarman
Guest Editor

Manuscript Submission Information

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• gut microbiota dynamics (structural/morphological/anatomical changes, eubiosis, and dysbiosis)
• exploring healthy gut microbiota
• gut microbiota, host genetics, and epigenetics
• gut microbiota shotgun metagenomics, single-cell sequencing, CRISPR editing, and spatial profiling
• transcriptomics, proteomics, and metabolomics
• mitochondrial bioenergetics and metabolism
• mitochondrial signaling
• personalized and precision microbiome therapies
• microbial metabolites as therapeutics
• gut–brain axis and neuroactive microbes
• gut–brain axis in cardio-pulmonary vascular diseases
• gut involvement in metabolic diseases
• gut microbiota in immune-oncology and cancer