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Microorganisms
Special Issues
Research on Replication Mechanisms and Molecular Virology of Influenza Virus
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Research on Replication Mechanisms and Molecular Virology of Influenza Virus

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Virology".

Deadline for manuscript submissions: 15 July 2024 | Viewed by 923

Special Issue Editors

Prof. Dr. Sang-Ik Park

E-Mail Website
Guest Editor
Laboratory of Veterinary Pathology, College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju, Republic of Korea
Interests: virology; pathology; antiviral therapy; zoonotic diseases; molecular biology
Dr. Yeong-Bin Baek

E-Mail Website
Guest Editor
Laboratory of Veterinary Pathology, College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of Korea
Interests: molecular virology; host-microbe interactions; viral pathology; antiviral therapeutics; microbiology
Dr. Jun-Gyu Park

E-Mail Website
Guest Editor
Laboratory of Veterinary Zoonotic Diseases, College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of Korea
Interests: zoonotic diseases; molecular microbiology; epidemiology; vaccine development; public health

Special Issue Information

Dear Colleagues,

Throughout history, RNA viruses like influenza have caused severe damage to humans and animals. It is essential to understand the molecular characteristics of these viruses to develop effective antiviral drugs and disease control methods in a constantly changing world. Despite the significant progress made in the field, there are still fundamental questions that remain unanswered, such as the completion of the viral replication cycle, the molecular mechanisms involved in the host and the virus, and the target factors for controlling viral replication.

This Special Issue aims to provide a comprehensive overview of the current knowledge on influenza virus infection by collating the latest research. By gathering research to understand viral interactions with the host and replication mechanisms, we can develop effective antiviral strategies and better prepare for future pandemics.

As the Guest Editor of this Special Issue, I warmly invite you to submit research articles, review articles, and short communications related to the aforementioned topics. We are excited to assemble an issue that highlights some of the most compelling current research on the replication mechanisms and molecular virology of influenza virus.

Prof. Dr. Sang-Ik Park
Dr. Yeong-Bin Baek
Dr. Jun-Gyu Park
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • the molecular characterization of influenza infection
  • host–virus interaction
  • the mechanism of viral replication
  • virus life cycle: attachment, penetration, uncoating, replication, assembly, maturation, and release cellular factors involved in the virus life cycle
  • host immune system during infection
  • novel antiviral strategy
  • insights on future antiviral drug
  • novel vaccine strategy

Published Papers (1 paper)

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Research

16 pages, 2943 KiB  
Article
A Noble Extract of Pseudomonas sp. M20A4R8 Efficiently Controlling the Influenza Virus-Induced Cell Death
by Su-Bin Jung, Grace Choi, Hyo-Jin Kim, Kyeong-Seo Moon, Gun Lee, Kyeong-Hak Na, Yong Min Kwon, Jimin Moon, Mi Yeong Shin, Jae-Yeong Yu, Yeong-Bin Baek, Jun-Gyu Park and Sang-Ik Park
Microorganisms 2024, 12(4), 677; https://doi.org/10.3390/microorganisms12040677 - 28 Mar 2024
Viewed by 757
Abstract
Epidemic diseases that arise from infectious RNA viruses, particularly influenza viruses, pose a constant threat to the global economy and public health. Viral evolution has undermined the efficacy of acquired immunity from vaccines and the antiviral effects of FDA-approved drugs. As such, there [...] Read more.
Epidemic diseases that arise from infectious RNA viruses, particularly influenza viruses, pose a constant threat to the global economy and public health. Viral evolution has undermined the efficacy of acquired immunity from vaccines and the antiviral effects of FDA-approved drugs. As such, there is an urgent need to develop new antiviral lead agents. Natural compounds, owing to their historical validation of application and safety, have become a promising solution. In this light, a novel marine bacterium, Pseudomonas sp. M20A4R8, has been found to exhibit significant antiviral activity [half maximal inhibitory concentration (IC50) = 1.3 µg/mL, selectivity index (SI) = 919.4] against influenza virus A/Puerto Rico/8/34, surpassing the activity of chloroquine. The antiviral response via M20A4R8 extract was induced during post-entry stages of the influenza virus, indicating suitability for post-application after the establishment of viral infection. Furthermore, post-treatment with M20A4R8 extract protected the host from virus-induced apoptosis, suggesting its potential use in acute respiratory disease complexes resulting from immune effectors’ overstimulation and autophagy-mediated self-apoptosis. The extract demonstrated an outstanding therapeutic index against influenza virus A/Wisconsin/15/2009 (IC50 = 8.1 µg/mL, SI = 146.2) and B/Florida/78/2015 Victoria lineage (IC50 = 3.5 µg/mL, SI = 343.8), indicating a broad anti-influenza virus activity with guaranteed safety and effectiveness. This study provides a new perspective on mechanisms for preventing a broad spectrum of viral infections through antiviral agents from novel and natural origins. Future studies on a single or combined compound from the extract hold promise, encouraging its use in preclinical challenge tests with various influenza virus strains. Full article
(This article belongs to the Special Issue Research on Replication Mechanisms and Molecular Virology of Influenza Virus)
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