Antimicrobial Impact of Probiotic Bacteria

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Food Microbiology".

Deadline for manuscript submissions: closed (30 April 2022) | Viewed by 8127

Special Issue Editor

Department of Botany and Microbiology, College of Sciences, Riyadh, Saudi Arabia
Interests: lactobacillus; dairy products; antimicrobial activities

Special Issue Information

Dear Colleagues,

In 2017, the World Health Organization listed the antibiotics required for combating the effects of pathogenic bacteria including Enterococcus spp., Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Psedomonas aeruginosa, and Enterobacter sp. Pathogenic bacteria and their toxins often enter the human body via the consumption of food or drinks, leading to either symptoms or illness depending on different mechanisms. A rate of occurrence of approximately 502%  has been found in the normal flora of people for S. aureus and E. coli. This sometimes has a virulent nature, resistant to common antibiotics, causing sepsis and severe infection. In addition, enterococcal strains that dominate pathogenesis in the GIT tract are E. faecalis and E. faecium. Most enterococcal infections are developed by E. faecalis. Among enterococcal strains, E. faecium is strongly antibiotic resistant and very difficult to treat. The invention of antibiotics that can tackle pathogenic bacteria thus represents a significant step forward in the medical field in terms of controlling the deathly infections they cause. However, a larger number of antibiotics are being found to be ineffective against certain drug-resistant pathogens, and the global spread of these pathogens is leading to an increased number of infections that are difficult to treat and higher incidences of death. Therefore, new, alternative antibiotics are urgently required to control the spread of pathogens. In general, probiotics are represented as a potential alternative for antibiotics to control and prevent the spread of pathogenic bacteria. Strains belonging to lactic acid bacteria such as Lactobacillus and Bifidobacterium are commonly used as probiotics. These bacteria can produce various antimicrobial agents that exert a strong antagonistic activity against different pathogenic microbes. The mechanisms underlying LAB activity against pathogens appear to be multifactorial, taking the form of, e.g., the production of lactic acid, acetic acid, propionic acid, hydrogen peroxide, ethanol, diacetyl acetaldehyde, acetoine, reuterin, bacteriocines, peptides, and modulation of intestinal microbiota. This Special Issue aims to collect research or review articles related to the antimicrobial properties of Lactobacillus strains of different origin. Contributions are invited on different disciplinary topics but not limited to:

  • Novel probiotic strains and products;
  • Screening of probiotic strains for biological activities;
  • Antioxidant potentials of probiotic bacteria;
  • Diversity of probiotic bacteria from foods;
  • Lactobacillus in food packaging;
  • Lactobacillus in food preservation;
  • Lactobacillus in intestinal health;
  • Probiotic drink for teeth protection.

We look forward to receiving your contributions.

Prof. Dr. Mariadhas Valan Arasu
Guest Editor

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Keywords

  • probiotic lactobacillus
  • antibacterial and antifungal activity
  • antioxidant activity
  • lactobacillus isolation from silage
  • lactobacillus metabolic products
  • food packaging
  • food preservation
  • diversity of LAB

Published Papers (2 papers)

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Research

21 pages, 2768 KiB  
Article
Dynamics of Changes in the Gut Microbiota of Healthy Mice Fed with Lactic Acid Bacteria and Bifidobacteria
by Mariya Gryaznova, Yulia Dvoretskaya, Inna Burakova, Mikhail Syromyatnikov, Evgeny Popov, Anastasia Kokina, Evgeny Mikhaylov and Vasily Popov
Microorganisms 2022, 10(5), 1020; https://doi.org/10.3390/microorganisms10051020 - 12 May 2022
Cited by 24 | Viewed by 3730
Abstract
Probiotics are living microorganisms that provide numerous health benefits for their host. Probiotics have various effects on the body; for example, they change gut microbiota, improve the integrity of the epithelial barrier and have anti-inflammatory effects. The use of probiotic supplements that are [...] Read more.
Probiotics are living microorganisms that provide numerous health benefits for their host. Probiotics have various effects on the body; for example, they change gut microbiota, improve the integrity of the epithelial barrier and have anti-inflammatory effects. The use of probiotic supplements that are based on lactic acid bacteria and bifidobacteria is one of the approaches that are used to balance gut microflora. In our study, we evaluated the effects of supplements, which were based on members of the Lactobacillaceae family and bifidobacteria, on the gut microbiome of healthy mice using the 16S rRNA sequencing method. The data that were obtained demonstrated that when mice received the probiotic supplements, statistically significant changes occurred in the composition of the microbiome at the phylum level, which were characterized by an increase in the number of Actinobacteriota, Bacteroidota, Verrucomicrobia and Proteobacteria, all of which have potentially positive effects on health. At the generic level, a decrease in the abundance of members of the Nocardioides, Helicobacter and Mucispirillum genus, which are involved in inflammatory processes, was observed for the group of mice that was fed with lactic acid bacteria. For the group of mice that was fed with bifidobacteria, a decrease was seen in the number of members of the Tyzzerella and Akkermansia genus. The results of our study contribute to the understanding of changes in the gut microbiota of healthy mice under the influence of probiotics. It was shown that probiotics that are based on members of the Lactobacillaceae family have a more positive effect on the gut microbiome than probiotics that are based on bifidobacteria. Full article
(This article belongs to the Special Issue Antimicrobial Impact of Probiotic Bacteria)
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12 pages, 4366 KiB  
Article
Isolation of Lactococcus lactis from Whole Crop Rice and Determining Its Probiotic and Antimicrobial Properties towards Gastrointestinal Associated Bacteria
by Ilavenil Soundharrajan, Yong Hee Yoon, Karnan Muthusamy, Jeong-Sung Jung, Hyun Jeong Lee, Ouk-Kyu Han and Ki Choon Choi
Microorganisms 2021, 9(12), 2513; https://doi.org/10.3390/microorganisms9122513 - 03 Dec 2021
Cited by 7 | Viewed by 3711
Abstract
Antimicrobial resistance is an emerging condition that increases the risk of spreading and prolonging infectious diseases globally. Therefore, a new alternative strategy for antibiotics is required urgently to control pathogens spreading. Probiotics are considered as an alternative for antibiotics that inhibit pathogens. In [...] Read more.
Antimicrobial resistance is an emerging condition that increases the risk of spreading and prolonging infectious diseases globally. Therefore, a new alternative strategy for antibiotics is required urgently to control pathogens spreading. Probiotics are considered as an alternative for antibiotics that inhibit pathogens. In the present study, potent lactic acid bacteria (LAB) were isolated and screened for their probiotic characteristics and antagonistic activity against intestinal pathogens by agar well diffusion, Time and Dose-dependent killing assay, minimum inhibitor, and minimum bactericidal concentration (MIC/MBC), and co-culture methods. The Lactococcus lactis RWP-3 and RWP-7 fermented the different carbohydrate substrates and produced different extracellular enzymes. Both isolates showed significant tolerant capability in the gastric, duodenal, and intestinal juices. In addition, RWP-3 and RWP-7 had hydrophobicity and aggregation properties in a time-dependent manner. Furthermore, the cell-free secondary metabolites (CFS) of RWP-3 and RWP-7 showed strong antibacterial activity against Escherichia coli,Staphylococcus aureus, Pseudomonas aeruginosa and Enterococcus faecalis. A co-culture study revealed that the RWP-3 and RWP-7 strongly compete with pathogen growths. RWP-3 and RWP-7 showed strong antagonistic activities against tested pathogens with significant probiotic characteristics, suggesting that these strains obtained could be used as an alternative strategy for the antibiotic to control infectious pathogens. Full article
(This article belongs to the Special Issue Antimicrobial Impact of Probiotic Bacteria)
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