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Microorganisms
Special Issues
Molecular Mechanism of Microbial Heat Adaptation
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Molecular Mechanism of Microbial Heat Adaptation

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Molecular Microbiology and Immunology".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 690

Special Issue Editor

Prof. Dr. Binguang Ma

E-Mail Website
Guest Editor
Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan 430070, China
Interests: microbial genomics; molecular networks; protein structures; temperature adaptation; gene regulation

Special Issue Information

Dear Colleagues,

Temperature is one of the most important factors for the survival of all living organisms. Microbes need sensing and defense mechanisms to adapt to changes in temperature. They adapt to high temperatures through a series of biological processes at the cellular and molecular levels. This Special Issue, “Molecular Mechanism of Microbial Heat Adaptation”, focuses on the molecular mechanisms of microbial heat adaptation, including the changes in nucleic acid structure and regulatory relationship, gene recombination, DNA damage repair, protein structural stability and metabolic adaptation to a high-temperature environment. We welcome researchers who conduct research related to the molecular mechanisms of microbial thermal adaptation to submit research papers or review articles to this Special Issue.

Prof. Dr. Binguang Ma
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microbial genomics
  • molecular networks
  • protein structures
  • temperature adaptation
  • gene regulation

Published Papers (1 paper)

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Research

16 pages, 4428 KiB  
Article
Spatial Chromosome Organization and Adaptation of Escherichia coli under Heat Stress
by Xu-Ting Wang and Bin-Guang Ma
Microorganisms 2024, 12(6), 1229; https://doi.org/10.3390/microorganisms12061229 - 19 Jun 2024
Viewed by 507
Abstract
The spatial organization of bacterial chromosomes is crucial for cellular functions. It remains unclear how bacterial chromosomes adapt to high-temperature stress. This study delves into the 3D genome architecture and transcriptomic responses of Escherichia coli under heat-stress conditions to unravel the intricate interplay [...] Read more.
The spatial organization of bacterial chromosomes is crucial for cellular functions. It remains unclear how bacterial chromosomes adapt to high-temperature stress. This study delves into the 3D genome architecture and transcriptomic responses of Escherichia coli under heat-stress conditions to unravel the intricate interplay between the chromosome structure and environmental cues. By examining the role of macrodomains, chromosome interaction domains (CIDs), and nucleoid-associated proteins (NAPs), this work unveils the dynamic changes in chromosome conformation and gene expression patterns induced by high-temperature stress. It was observed that, under heat stress, the short-range interaction frequency of the chromosomes decreased, while the long-range interaction frequency of the Ter macrodomain increased. Furthermore, two metrics, namely, Global Compactness (GC) and Local Compactness (LC), were devised to measure and compare the compactness of the chromosomes based on their 3D structure models. The findings in this work shed light on the molecular mechanisms underlying thermal adaptation and chromosomal organization in bacterial cells, offering valuable insights into the complex inter-relationships between environmental stimuli and genomic responses. Full article
(This article belongs to the Special Issue Molecular Mechanism of Microbial Heat Adaptation)
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