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Microorganisms
Special Issues
Host–Microbiome Cross-Talk in Cancer Development and Progression
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Host–Microbiome Cross-Talk in Cancer Development and Progression

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Microbiomes".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 656

Special Issue Editor

Dr. Subhadeep Das

E-Mail Website
Guest Editor
Department of Biochemistry, Purdue University, West Lafayette, IN, USA
Interests: RNA biology; human diseases; eukaryotic stress response; cancer biology; microbiology; cell biology; biochemistry; biomaterials

Special Issue Information

Dear Colleagues,

The rapidly evolving field of cancer research highlights the human microbiome as a crucial factor influencing our understanding of tumor development and treatment outcomes. Recent findings indicate that exposure to certain microbial components or an imbalance in microbial communities may affect the risk, invasion, and progression of cancer. Next-generation sequencing platforms reveal a robust microbial population that not only thrives in the gastrointestinal system and other bodily locations but also thrives within tumor tissues. This broad microbiota, consisting of bacteria, viruses, and fungi, exhibits unique signatures in different types of cancer. This Special Issue aims to highlight recent advances that explore the cross-talk between microbiome research and cancer, as well as potential mechanisms that may contribute to cancer promotion.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  1. Exploring the impact of dietary factors on the relationship between the microbiome and cancer.
  2. Various bioinformatic and deep learning approaches to understand host–microbiome interactions in the context of tumor progression.
  3. How microbial metabolites influence tumor progression by altering epigenetic responses in host cells.
  4. The role of the microbiome in influencing immune surveillance and the mechanisms of tumor immune evasion.

I look forward to receiving your contributions.

Dr. Subhadeep Das
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dietary factors
  • epigenetic responses
  • bioinformatic and deep learning techniques
  • therapy
  • tumor microenvironment
  • microbiome-targeted therapies

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Published Papers (1 paper)

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Research

20 pages, 10628 KiB  
Article
Temporal and Spatial Dynamics of Tumor–Host Microbiota in Breast Cancer Progression
by Qi Xu, Aikun Fu, Nan Wang and Zhizhen Zhang
Microorganisms 2025, 13(7), 1632; https://doi.org/10.3390/microorganisms13071632 - 10 Jul 2025
Viewed by 492
Abstract
Deciphering the spatiotemporal distribution of bacteria during breast cancer progression may provide critical insights for developing bacterial-based therapeutic strategies. Using a murine breast cancer model, we longitudinally profiled the microbiota in breast tumor tissue, mammary gland, spleen, and cecal contents at 3-, 5-, [...] Read more.
Deciphering the spatiotemporal distribution of bacteria during breast cancer progression may provide critical insights for developing bacterial-based therapeutic strategies. Using a murine breast cancer model, we longitudinally profiled the microbiota in breast tumor tissue, mammary gland, spleen, and cecal contents at 3-, 5-, and 7- weeks post-tumor implantation through 16S rRNA gene sequencing. Breast tumor progression was associated with lung metastasis and splenomegaly, accompanied by distinct tissue-specific microbial dynamics. While alpha diversity remained stable in tumors, mammary tissue, and cecal contents, it significantly increased in the spleen (p < 0.05). Longitudinal analysis revealed a progressive rise in Firmicutes and a decline in Proteobacteria abundance within tumors, mammary tissue, and cecum, whereas the spleen microbiota displayed unique phylum-level compositional shifts. Tissue- and time-dependent microbial signatures were identified at phylum, genus, and species levels during breast tumor progression. Strikingly, the spleen microbiota integrated nearly all genera enriched in other sites, suggesting its potential role as a microbial reservoir. Gut-associated genera (Lactobacillus, Desulfovibrio, Helicobacter) colonized both cecal contents and the spleen, with Lactobacillus consistently detected across all tissues, suggesting microbial translocation. The spleen exhibited uniquely elevated diversity and compositional shifts, potentially driving splenomegaly. These results delineated the trajectory of microbiota translocation and colonization, and demonstrated tissue-specific microbial redistribution during breast tumorigenesis, offering valuable implications for advancing microbiome-targeted cancer therapies. Full article
(This article belongs to the Special Issue Host–Microbiome Cross-Talk in Cancer Development and Progression)
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