Recent Advances of Microbiome Researches in One Health and Their Potential Applications

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Microbiomes".

Deadline for manuscript submissions: closed (30 April 2025) | Viewed by 344

Special Issue Editor


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Guest Editor
Department of Clinical Laboratory and Pathology, Hong Kong Adventist Hospital, Hong Kong SAR, China
Interests: microbial metagenomics; molecular testing; infectious diseases
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Special Issue Information

Dear Colleagues,

One Health is an integrated and unifying approach that enhances the collaboration between humans, animals, and ecosystem health sectors to address the full spectrum of related issues, including but not limited to: infectious disease diagnosis, surveillance, prevention, and control; antimicrobial resistance; food safety; and environmental health. In the One Health domain, microbiomes play a crucial role.

As the Guest Editor of this Special Issue, I am pleased to invite you to submit original research articles, experiences, or reviews on the recent advances of microbiome research in One Health and their potential applications to improve human health. Including but not limited to:

The human microbiome: the collection explores the role of the human microbiome in health and disease, including the gut, skin, oral, and vaginal microbiota, and their impact on metabolic disorders, immune responses, and reproductive health.

The animal microbiome: it delves into the microbiomes of animals, highlighting their influence on livestock production, wildlife conservation, and the transmission of zoonotic diseases.

The environmental microbiome: the Special Issue examines the role of environmental and soil microbiomes in ecosystem health, substance cycling, and their interplay with human and animal health.

The One Health microbiome model: articles within this issue discuss the One Health microbiome model, emphasizing the need for a holistic approach to maintaining a healthy ecosystem and the potential for novel microbiome-based interventions.

Dr. Hin Fung Tsang
Guest Editor

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Keywords

  • microbiome
  • one health
  • antimicrobial resistance
  • food safety
  • environmental health

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Published Papers (1 paper)

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Research

20 pages, 2642 KiB  
Article
Complete Genome and Characterization Analysis of a Bifidobacterium animalis Strain Isolated from Wild Pigs (Sus scrofa ussuricus)
by Tenggang Di, Huan Zhang, Cheng Zhang, Liming Tian, Menghan Chang, Wei Han, Ruiming Qiao, Ming Li, Shuhong Zhang and Guangli Yang
Microorganisms 2025, 13(7), 1666; https://doi.org/10.3390/microorganisms13071666 - 16 Jul 2025
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Abstract
Bifidobacterium is a predominant probiotic in animals that is associated with host intestinal health. The protective mechanisms of the Bifidobacterium animalis (B. animalis) strain, specifically those related to functional gene–host interactions in intestinal homeostasis, remain poorly elucidated. This study reports the [...] Read more.
Bifidobacterium is a predominant probiotic in animals that is associated with host intestinal health. The protective mechanisms of the Bifidobacterium animalis (B. animalis) strain, specifically those related to functional gene–host interactions in intestinal homeostasis, remain poorly elucidated. This study reports the complete genome sequence and characterization of a B. animalis strain isolated from wild pig feces, which comprised a single circular chromosome (1,944,022 bp; GC content 60.49%) with 1567 protein-coding genes, and the B. animalis strain had certain acid resistance, bile salt resistance, gastrointestinal fluid tolerance, and antibacterial characteristics. Genomic annotation revealed three putative genomic islands and two CRISPR-Cas systems. Functional characterization identified genes encoding carbohydrate-active enzymes (CAZymes) and associated metabolic pathways, indicating that this strain can degrade complex dietary carbohydrates and synthesize bioactive metabolites for gut homeostasis. Although the antibiotic resistance genes were predicted, phenotypic assays demonstrated discordant resistance patterns, indicating complex regulatory networks. This study indicated the genomic basis of Bifidobacterium–host crosstalk in intestinal protection, providing a framework for developing novel probiotic interventions. Full article
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