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Microorganisms
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Bacteria Control by Phages
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Bacteria Control by Phages

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Medical Microbiology".

Deadline for manuscript submissions: 31 October 2024 | Viewed by 1766

Special Issue Editors

Dr. Lanying Zeng

E-Mail Website
Guest Editor
1. Department of Biochemistry and Biophysics, Texas A&M University, 2128 TAMU, College Station, TX 77843, USA
2. Center for Phage Technology, Texas A&M University, 2128 TAMU, College Station, TX 77843, USA
Interests: Quantitative biology; cellular decision making; bacteriophages; bacterial pili; phage infection dynamics
Dr. Junjie Zhang

E-Mail Website
Guest Editor
Center for Phage Technology, Department of Biochemistry and Biophysics, Texas A&M University, 300 Olsen Blvd., College Station, TX 77843, USA
Interests: structural biology; viruses; bacteria; drug development; pathogen-host interactions

Special Issue Information

Dear Colleagues,

Bacteriophages (phages) are viruses that specifically target and infect bacteria. They represent the most abundant and diverse biological entities on Earth. Recently, phages have regained attention as therapeutic agents, driven by their connection to human microbiota and the growing battle against antibiotic-resistant pathogens resulting from broad-spectrum antibiotic use.

Unlike most small-molecule drugs, phages possess inherent specificity against their host bacterial species. Additionally, advances in molecular biology and genomics have unveiled an astounding array of phages in the biosphere, including the normal human microbiota. This vast resource offers a potentially limitless supply of safe natural antimicrobials suitable for use within the human body.

In recent breakthroughs, phage therapy has effectively treated patients afflicted with previously "untreatable" multidrug-resistant infections. This collection seeks to consolidate current phage research across various domains, aiming to enhance our understanding of bacterial control. Topics covered include, but are not limited to, phage lysis-lysogeny decision making and switch, infection dynamics, phage assembly, host–phage interactions, infection cycles, and phage therapy.

Dr. Lanying Zeng
Dr. Junjie Zhang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • phage therapy
  • host specificity
  • phage entry
  • phage biology
  • phage engineering
  • phage lysis
  • phage lysis-lysogeny switch
  • anti-phage defense
  • infection cycle

Published Papers (2 papers)

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Research

15 pages, 1982 KiB  
Article
Partial Characterization of Three Bacteriophages Isolated from Aquaculture Hatchery Water and Their Potential in the Biocontrol of Vibrio spp.
by İhsan Yaşa, Serap Evran, Asiye Esra Eren Eroğlu, Cengiz Önder, Maryam Allahyari, Gülçin Menderes and Müberra Kullay
Microorganisms 2024, 12(5), 895; https://doi.org/10.3390/microorganisms12050895 - 29 Apr 2024
Viewed by 381
Abstract
Bacteriophages are currently considered one of the most promising alternatives to antibiotics under the ‘One Health’ approach due to their ability to effectively combat bacterial infections. This study aimed to characterize Vibrio species in hatchery water samples collected from an aquaculture farm and [...] Read more.
Bacteriophages are currently considered one of the most promising alternatives to antibiotics under the ‘One Health’ approach due to their ability to effectively combat bacterial infections. This study aimed to characterize Vibrio species in hatchery water samples collected from an aquaculture farm and investigate the biocontrol potential of their bacteriophages. Vibrio spp. (n = 32) isolates confirmed by LNA probe-based qPCR were used as hosts. Three Vibrio phages were isolated. IKEM_vK exhibited a broad host range, infecting V. harveyi (n = 8), V. alginolyticus (n = 2), V. azureus (n = 1), and V. ordalii (n = 1). IKEM_v5 showed lytic activity against V. anguillarum (n = 4) and V. ordalii (n = 1), while IKEM_v14 was specific to V. scophtalmi (n = 4). The morphological appearance of phages and their lytic effects on the host were visualized using scanning electron microscopy (SEM). All three phages remained relatively stable within the pH range of 6–11 and up to 60 °C. The lytic activities and biofilm inhibition capabilities of these phages against planktonic Vibrio cells support their potential applications in controlling vibriosis in aquaculture systems. Full article
(This article belongs to the Special Issue Bacteria Control by Phages)
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17 pages, 5780 KiB  
Article
Genomic and Phenotypic Analysis of Salmonella enterica Bacteriophages Identifies Two Novel Phage Species
by Sudhakar Bhandare, Opeyemi U. Lawal, Anna Colavecchio, Brigitte Cadieux, Yella Zahirovich-Jovich, Zeyan Zhong, Elizabeth Tompkins, Margot Amitrano, Irena Kukavica-Ibrulj, Brian Boyle, Siyun Wang, Roger C. Levesque, Pascal Delaquis, Michelle Danyluk and Lawrence Goodridge
Microorganisms 2024, 12(4), 695; https://doi.org/10.3390/microorganisms12040695 - 29 Mar 2024
Viewed by 995
Abstract
Bacteriophages (phages) are potential alternatives to chemical antimicrobials against pathogens of public health significance. Understanding the diversity and host specificity of phages is important for developing effective phage biocontrol approaches. Here, we assessed the host range, morphology, and genetic diversity of eight Salmonella [...] Read more.
Bacteriophages (phages) are potential alternatives to chemical antimicrobials against pathogens of public health significance. Understanding the diversity and host specificity of phages is important for developing effective phage biocontrol approaches. Here, we assessed the host range, morphology, and genetic diversity of eight Salmonella enterica phages isolated from a wastewater treatment plant. The host range analysis revealed that six out of eight phages lysed more than 81% of the 43 Salmonella enterica isolates tested. The genomic sequences of all phages were determined. Whole-genome sequencing (WGS) data revealed that phage genome sizes ranged from 41 to 114 kb, with GC contents between 39.9 and 50.0%. Two of the phages SB13 and SB28 represent new species, Epseptimavirus SB13 and genera Macdonaldcampvirus, respectively, as designated by the International Committee for the Taxonomy of Viruses (ICTV) using genome-based taxonomic classification. One phage (SB18) belonged to the Myoviridae morphotype while the remaining phages belonged to the Siphoviridae morphotype. The gene content analyses showed that none of the phages possessed virulence, toxin, antibiotic resistance, type I–VI toxin–antitoxin modules, or lysogeny genes. Three (SB3, SB15, and SB18) out of the eight phages possessed tailspike proteins. Whole-genome-based phylogeny of the eight phages with their 113 homologs revealed three clusters A, B, and C and seven subclusters (A1, A2, A3, B1, B2, C1, and C2). While cluster C1 phages were predominantly isolated from animal sources, cluster B contained phages from both wastewater and animal sources. The broad host range of these phages highlights their potential use for controlling the presence of S. enterica in foods. Full article
(This article belongs to the Special Issue Bacteria Control by Phages)
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