The Oral Microbiota and Oral Health

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Medical Microbiology".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 3923

Special Issue Editor


E-Mail Website
Guest Editor
Department of Pediatric Dentistry, Nihon University School of Dentistry at Matsudo, Matsudo 271-8587, Japan
Interests: oral bacteria; biofilm; immunology

Special Issue Information

Dear Colleagues,

A healthy oral microbiome is an important factor that affects not only the oral cavity but also the whole body. Due to the disruption of the oral microbiota, caries and periodontal disease progress in the oral cavity. An important issue in maintaining oral health is maintaining a healthy oral microbiological flora through oral care. Various factors are involved, including lifestyle habits, oral hygiene, systemic diseases, saliva secretion, and immunity. It is important to maintain commensal microbiota through control of oral biofilm formation. Therefore, research into control agents for oral biofilm should be made a priority. The beneficial effects of the microbiome, the importance of the balance between bacteria, the role of oral bacteria and host immune factors, and the establishment of preventive and therapeutic methods to maintain the balance of the oral microbiome provide the key framework for this special issue. 

Prof. Dr. Hidenobu Senpuku
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oral biofilm
  • oral microbiota
  • dental caries
  • periodontal diseases
  • oral cavity
  • lifestyle habit
  • Streptococcus mutans
  • Streptococcus mitis
  • Porphylomonas gingivalis
  • saliva

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Jump to: Review

15 pages, 1338 KiB  
Article
The Effect of Limosilactobacillus fermentum MG4717 on Oral Health and Biosafety
by Jeong-Yong Park, Ji Yeon Lee, YongGyeong Kim, Byoung-Kook Kim and Soo-Im Choi
Microorganisms 2025, 13(7), 1600; https://doi.org/10.3390/microorganisms13071600 - 7 Jul 2025
Viewed by 287
Abstract
Oral diseases such as periodontitis and dental caries, as well as conditions related to oral health such as halitosis, are closely associated with dysbiosis of the oral microbiota and continue to pose significant public health challenges worldwide. With the increasing resistance to existing [...] Read more.
Oral diseases such as periodontitis and dental caries, as well as conditions related to oral health such as halitosis, are closely associated with dysbiosis of the oral microbiota and continue to pose significant public health challenges worldwide. With the increasing resistance to existing antibiotics and side effects of chemical disinfectants, probiotics have emerged as promising alternatives for oral healthcare. This study aimed to evaluate the oral health efficacy and probiotic properties of Limosilactobacillus fermentum (L. fermentum) MG4717 isolated from the human oral cavity. L. fermentum MG4717 showed notable antimicrobial activity against the key oral pathogens Streptococcus mutans (S. mutans), Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans), Porphyromonas gingivalis (P. gingivalis), and Fusobacterium nucleatum (F. nucleatum) and effectively inhibited biofilm formation. Additionally, L. fermentum MG4717 significantly downregulated methionine gamma-lyase (mgl) mRNA expression in P. gingivalis, which is implicated in halitosis and pathogenicity. L. fermentum MG4717 strongly adhered to the KB and HT-29 epithelial cells and exhibited good resilience under simulated gastrointestinal conditions. Whole-genome sequencing (WGS) and average nucleotide identity (ANI) analysis confirmed strain identity (98.73% average nucleotide identity with L. fermentum DSM20052) and the absence of transferable antibiotic resistance genes. Safety assessments revealed no cytotoxicity, hemolytic activity, or bile salt hydrolase activity. These findings suggest that L. fermentum MG4717 has the potential to be used as a safe and effective oral probiotic beneficial for oral health. Full article
(This article belongs to the Special Issue The Oral Microbiota and Oral Health)
Show Figures

Figure 1

Review

Jump to: Research

33 pages, 1926 KiB  
Review
Candida Infections: The Role of Saliva in Oral Health—A Narrative Review
by Riyoko Tamai and Yusuke Kiyoura
Microorganisms 2025, 13(4), 717; https://doi.org/10.3390/microorganisms13040717 - 23 Mar 2025
Cited by 1 | Viewed by 3308
Abstract
Candida species, particularly Candida albicans, are causative agents of oral infections to which immunocompromised patients are especially susceptible. Reduced saliva flow (xerostomia) can lead to Candida overgrowth, as saliva contains antibacterial components such as histatins and β-defensins that inhibit fungal growth and [...] Read more.
Candida species, particularly Candida albicans, are causative agents of oral infections to which immunocompromised patients are especially susceptible. Reduced saliva flow (xerostomia) can lead to Candida overgrowth, as saliva contains antibacterial components such as histatins and β-defensins that inhibit fungal growth and adhesion to the oral mucosa. Candida adheres to host tissues, forms biofilms, and secretes enzymes required for tissue invasion and immune evasion. Secretory asparaginyl proteinases (Saps) and candidalysin, a cytolytic peptide toxin, are vital to Candida virulence, and agglutinin-like sequence (Als) proteins are crucial for adhesion, invasion, and biofilm formation. C. albicans is a risk factor for dental caries and may increase periodontal disease virulence when it coexists with Porphyromonas gingivalis. Candida infections have been suggested to heighten the risk of oral cancer based on a relationship between Candida species and oral squamous cell carcinoma (OSCC) or oral potentially malignant disorder (OPMD). Meanwhile, β-glucan in the Candida cell wall has antitumor effects. In addition, Candida biofilms protect viruses such as herpesviruses and coxsackieviruses. Understanding the intricate interactions between Candida species, host immune responses, and coexisting microbial communities is essential for developing preventive and therapeutic strategies against oral Candida infections, particularly in immunocompromised individuals. Full article
(This article belongs to the Special Issue The Oral Microbiota and Oral Health)
Show Figures

Figure 1

Back to TopTop