Molecular Epidemiology, Virulence and Drug Resistance Mechanisms of Bacteria

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Molecular Microbiology and Immunology".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 947

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Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe 444a, 11042 Belgrade, Serbia
Interests: antibiotic resistance mechanism; antibiotic resistance regulation; gram-negative bacteria; Acinetobacter baumannii
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Special Issue Information

Dear Colleagues,

Antimicrobial resistance represents a significant and contemporary threat to global health. This Special Issue will present the latest advances in the understanding of the epidemiology, pathogenicity, and resistance of bacterial pathogens. It will include research at the cutting-edge of genomic epidemiology, the molecular determinants of virulence, and the evolution of antibiotic resistance on a global scale. In the post-antibiotic era, knowledge of the mechanisms responsible for antimicrobial resistance and virulence of pathogenic bacteria is of great importance since it could lead to the discovery of novel potential therapeutic targets. The objective of this Special Issue is to collate high-quality manuscripts (including research articles, case reports, short communications, and reviews) relevant to this topic, which will enhance our understanding of these threats to public health. We would be grateful to receive your valuable contributions.

Dr. Katarina Novović
Guest Editor

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Keywords

  • bacterial epidemiology
  • virulence
  • antimicrobial resistance
  • clinical microbiology
  • multidrug resistant bacteria
  • global clones

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Published Papers (1 paper)

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Research

13 pages, 576 KB  
Article
Molecular Characterization of Streptococcus pyogenes Isolates Recovered from Hospitalized Patients During the Years 2023–2024
by Adile A. Muhtarova, Vasil S. Boyanov, Alexandra S. Alexandrova and Raina T. Gergova
Microorganisms 2025, 13(9), 2148; https://doi.org/10.3390/microorganisms13092148 - 15 Sep 2025
Viewed by 521
Abstract
In recent years, the incidence of severe Streptococcus pyogenes (group A Streptococcus, GAS) infections has been increasing worldwide, similar to trends observed prior to the COVID-19 pandemic, alongside a rise in antibiotic resistance. In the present study, we identified the circulating 12 emm [...] Read more.
In recent years, the incidence of severe Streptococcus pyogenes (group A Streptococcus, GAS) infections has been increasing worldwide, similar to trends observed prior to the COVID-19 pandemic, alongside a rise in antibiotic resistance. In the present study, we identified the circulating 12 emm types and 8 clusters of 70 GAS isolates among inpatients, investigated their association with antibiotic susceptibility, and compared these findings with earlier research conducted in our country. The predominant emm types and clusters were emm1, emm3, and emm4, and A-C3, E4, and, A-C5, respectively. emm1 was the most common among patients with skin and soft tissue infections or pneumonia, while emm3 was detected in patients with peritonsillar abscesses. All isolates demonstrated susceptibility to penicillin and linezolid, whereas the prevalence of resistance to macrolides, lincosamides, and tetracyclines was found to be 14.3%, 14.3%, and 18.6%, respectively. A notable change in the distribution of emm-types/clusters has been observed, with emm1/A-C3 now identified as the most prevalent, differing from our previous study conducted in the pre-COVID-19 period. Additionally, we noted a decrease in resistance to macrolides attributed to a lower prevalence of emm28 clone. The current research is important for monitoring isolates responsible for severe infections, which is crucial for GAS surveillance. Full article
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