Microbiomes in Health and Disease

Dear Colleagues,

The complex and dynamic relationship between hosts and their associated microbiomes has emerged as a critical factor in understanding the pathogenesis and progression of various human diseases. Recent advancements in high-throughput omics technologies have enabled a more comprehensive understanding of this complex system, providing novel insights into the molecular mechanisms underlying host–microbiome interactions and their influences on health and disease.

From metabolic disorders like obesity and diabetes to autoimmune diseases, neurodegenerative conditions, and even cancer, the microbiome is now recognized as a key player in both the onset and progression of numerous health conditions. Furthermore, the gut–brain axis has highlighted the intricate communication between the microbiome and the central nervous system, opening new avenues for understanding mental health and neurological disorders.

In addition to its role in human health, the microbiome also holds promise for therapeutic innovation. Emerging treatments such as probiotics, prebiotics, synbiotics, and fecal microbiota transplantation are being explored as novel strategies to restore microbial balance and improve patient outcomes. However, significant gaps remain in our understanding of the mechanisms underlying microbiome–host interactions, the factors influencing microbial diversity, and the long-term effects of microbiome-targeted therapies.

This topical collection aims to bring together groundbreaking research that explores the complex relationships between microbiomes and human health, as well as their implications for disease prevention, diagnosis, and treatment. We welcome contributions that advance our knowledge of microbiome science, from basic research to clinical applications, and provide insights into how microbiomes can be harnessed to improve human health.

• Human microbiome
• Gut microbiome
• Host–microbiome interactions
• Gut–Brain Axis
• Prebiotics, Probiotics, Synbiotics, and Postbiotics
• Metabolic Disorders
• Immune System
• Fecal Microbiota Transplantation
• Autoimmune Diseases
• Therapeutic Interventions
• Mcrobiome-associated diseases
• Omics technologies
• Multi-omics integration
• Microbial network
• Bioinformatics and computational tools

Prof. Dr. Pabulo H. Rampelotto
Collection Editor

Manuscript Submission Information

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