Metabolic and Lipidomic Reprogramming in Cancer: Mechanisms and Therapeutic Potential
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Cell Metabolism".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 69
Special Issue Editors
Interests: stable isotope metabolomics; lipidomics; nuclear magnetic resonance; mass spectrometry; metabolism; cancer biology; cancer hallmarks; metabolic reprogramming
Special Issue Information
Dear Colleagues,
Cancer cells undergo profound metabolic and lipidomic reprogramming to sustain rapid proliferation, evade apoptosis, and adapt to dynamic microenvironments. These alterations reflect a fundamental rewiring of cellular energetics and biosynthetic pathways that directly contribute to malignancy. Recent advances in metabolomic and lipidomic technologies have revealed that shifts in energy metabolism, lipid synthesis and degradation, and signaling pathways are pivotal drivers of oncogenesis and disease progression.
This Special Issue centers on the mechanistic understanding of how cancer cells reconfigure their metabolic and lipid profile in response to genetic, environmental, and therapeutic factors. We welcome original research and review articles that explore the application of metabolomics and lipidomics, including the use of stable isotope tracers, to elucidate key pathways involved in cancer hallmarks. Emphasis is placed on integrative studies that investigate metabolic perturbations in response to drug treatments, nutrient availability, and microenvironmental stressors. Our objective is to highlight the critical roles of altered metabolic and lipidomic pathways in cancer initiation, promotion, progression, therapy resistance, and recurrence. By showcasing these molecular adaptations, this issue aims to advance precision oncology through identification of new diagnostic markers and targetable metabolic vulnerabilities, ultimately leading to improved therapeutic strategies.
Dr. Sara Vicente-Muñoz
Dr. Mariaelena Pistoni
Guest Editors
Manuscript Submission Information
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Keywords
- cancer hallmarks
- metabolomics
- lipidomics
- stable isotopes
- biomarkers
- therapeutic targets
- metabolic pathways
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