Toxicokinetics and Metabolism
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Pharmacology and Drug Metabolism".
Deadline for manuscript submissions: closed (30 June 2021) | Viewed by 7926
Special Issue Editor
Interests: human metabolism; in vitro cell and tissue culture systems; in silico, toxicokinetics; toxicodynamics; cytochrome P450; UDP-glucuronosyltransferases; sulfotransferases; deiodinases; Good In Vitro method Practice (GIVIMP); thyroid disruptors
Special Issue Information
Dear colleagues,
Although metabolism was originally considered to be the inactivation or detoxification of foreign compounds, today it is generally accepted that metabolism-mediated effects are an important issue in regulatory toxicity. Learning from historical examples of in vitro genotoxicity methods including hepatic metabolic competent sources proposed for regulatory risk assessment, it is important for all in vitro methods dealing with toxic potency testing of compounds to carefully consider human metabolism-mediated effects. The role of metabolism is particularly important when examining chemically induced target system and target organ effects. As such, both kinetic processes and metabolism-mediated considerations need to be at the forefront of risk assessment strategies of the 21st century based on the integration of data generated from in vitro and in silico methods. For studying, e.g., metabolism pathways and species differences, conducting dose-selection, assessing effects of chemicals on endogenous metabolism or identifying bio-activation, a multitude of reliable and relevant in vitro and in silico test methods can be used.
The Special Issue will give insight into the new generation of in vitro and in silico toxicokinetic and toxicodynamic methods that identify chemical interference with the metabolism of endogenous compounds and physiological processes, including investigations of whether the effect is likely to be of human relevance. Using specific chemical-, metabolism- and biokinetic-dependent in vitro and in silico method indicators, the design of the most valuable and predictive integrated test strategies will be shown. The collection of contributions by the expert community in the field aims to stimulate discussion on the way forward in developing new risk assessment strategies for capturing complex target organ and target system toxicity effects and will show that adequate development, optimization, standardization and integration of the next generation of in vitro and in silico methods and globally harmonized coordination of efforts are critical in this process.
Dr. Sandra Coecke
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- human
- in vitro
- in silico
- new approach methods
- NAMs
- ADME toolbox
- ADME framework
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