Molecular Diagnostics and Clinical Management of Perioperative Inflammation and Metabolic Derangements
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".
Deadline for manuscript submissions: closed (15 December 2021) | Viewed by 368
Special Issue Editor
Interests: molecular; cellular and physiological mechanisms of perioperative inflammation; metabolic derangements; real-time molecular diagnostics at the bedside; novel therapies; molecular approaches; sophisticated technological platforms
Special Issue Information
Dear Colleagues,
Surgical practice has become increasingly complex over the last few decades. The ageing and frail patient populations presenting for surgery with multiple comorbidities represent higher risks for adverse postoperative outcomes. In addition, advances in surgical technologies nowadays offer a variety of novel surgical options for previously untreatable and advanced conditions. These translate to up to 3% of perioperative mortality after non-cardiac surgery. It also adversely affects approximately 15% of patients who suffer significant postoperative complications, including renal and respiratory impairment, myocardial injury or severe infections. Such postoperative morbidity also has implications to health status after leaving the hospital as it leads to reduced long-term survival and reduced health-related quality of life.
Considering the prevalence and impact of perioperative morbidity and mortality associated with technically successful major surgeries, improved molecular monitoring of crucial aspect of surgical insults on homeostasis is required. As inflammation and metabolic dysregulation are major common pathways linking patient co-morbidities, risk profiles and major postoperative complications, there is an urgent need to advance our diagnostic and monitoring capabilities to better understand such basic determinants of the perioperative complications.
This Special Issue of Metabolites is therefore open but not limited to translational science addressing the linkage between inflammation and metabolic alterations. Original patient-centred articles providing new molecular information on these issues, review articles on the major paradigms and novel technologies addressing either phenotypes or candidate targets are all welcome. Such strategies especially integration of metabolic and inflammatory datasets have already been useful in stratifying critically ill patients. Similarly, comprehensive, integrated analysis of molecular measurements should allow unbiased identification and monitoring pathological signals in the perioperative setting. Together with hypothesis-driven molecular characterization, this Special Issue is expected to highlight the state of art of “molecular perioperative medicine”.
Dr. Nándor Marczin
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- Cytokines
- Innate immunity
- Leukocytes
- Monocytes
- Oxidative stress
- Energetics
- Ischemia–reperfusion injury
- Surgical inflammation
- Postoperative complications
- Metabolic phenotyping
- Biomarkers
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.
