Nutrition and Metabolic Changes in Aging and Age-Related Diseases
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Nutrition and Metabolism".
Deadline for manuscript submissions: closed (15 April 2025) | Viewed by 3688
Special Issue Editor
Special Issue Information
Dear Colleagues,
In recent years, research on senescence has gained significant momentum, especially concerning its impact on nutrient homeostasis and the cellular metabolism. Senescence, the irreversible growth arrest of cells, plays a crucial role in aging and age-related diseases. While senescent cells cease to divide, they remain metabolically active and undergo profound changes in their metabolic profile. This process is not only a hallmark of aging but also a pivotal factor in the regulation of tissue function, inflammation, and disease progression. As senescent cells accumulate in tissues over time, they secrete a variety of bioactive molecules collectively known as the senescence-associated secretory phenotype (SASP), which can influence neighboring cells and the systemic metabolism.
The study of cellular metabolism during senescence has uncovered how nutrient utilization and metabolic pathways are altered as cells transition to this non-proliferative state. Key metabolic changes include the rewiring of the glucose and lipid metabolism, mitochondrial dysfunction, and increased oxidative stress, which contribute to the physiological decline observed in aging tissues. Furthermore, the interplay between nutrient-sensing pathways, such as the mechanistic target of rapamycin (mTOR) and the AMP-activated protein kinase (AMPK), and the induction of senescence has been a focal point in understanding how metabolic stress accelerates cellular aging.
This Special Issue is dedicated to exploring the relationship between senescence, nutrient metabolism, and health in humans. The topics of interest include (but are not limited to) metabolomic analyses of cellular senescence in different tissues, the impact of dietary interventions on the senescence-associated metabolic phenotype, the role of the metabolism in the immune response to senescent cells, and how nutrient-sensing pathways regulate the progression of cellular senescence. By investigating these areas, researchers can gain deeper insights into how senescence contributes to metabolic disorders, chronic diseases, and the aging process, ultimately paving the way for therapeutic interventions promoting healthy aging and combating age-related metabolic decline.
Dr. Qi Zhang
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- senescence
- metabolism
- nutrient homeostasis
- aging
- SASP (senescence-associated secretory phenotype)
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
