Lipidomics Volume 2
A special issue of Metabolites (ISSN 2218-1989).
Deadline for manuscript submissions: closed (31 May 2018)
Special Issue Editor
Interests: cryo-electron microscopy; lipid-protein interactions; biomolecular structure; lipidomics; mass spectrometry; analytical chemistry
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Lipids play diverse roles in biological systems: In addition to storing energy, they also act as structural scaffolds, modulators of membrane transport, and as signal transduction messengers. Increasing evidence from structural biology has established that detailed knowledge of lipid molecular structure is often required to fully appreciate the biochemical role of individual lipids.
Lipidomics, the comprehensive analysis of the lipid composition in a cell or tissue, has been driven by advances in analytical capabilities. These advances have been enabled primarily by mass spectrometry, a powerful tool for structural characterisation of lipids in biological samples. Methods for quantitative lipid analysis and detailed structural identification of unknown lipids are now well established. Contemporary instrumentation demonstrates ever-increasing sensitivity and resolution necessary for analysis of lipids in complex biological samples. Nevertheless, techniques complementary to mass spectrometry are highly valuable and have a role to play in lipid analysis. Furthermore, the ever-increasing complexity of data generated during lipidome analysis has required the development of novel tools for data analysis and feature mining in such datasets.
This Special Issue of Metabolites will be dedicated to the development of novel methods to characterize lipid structure, high-throughput lipidomics, characterization of lipid-protein interactions, clinical applications of lipidomics, and bioinformatic tools for analyzing large lipidomic datasets.
Dr. Simon H. J. Brown
Guest Editor
Manuscript Submission Information
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Keywords
- lipidomics
- lipid metabolism
- lipid profiling
- global profiling of lipids
- metabolic phenotype
- lipid biomarkers
- lipid-protein interactions
- membranes
- mass spectrometry
- high resolution
- untargeted lipidomics
- targeted lipidomics
- data mining
- databases
- clinical lipidomics
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