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Metabolites
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Chemical Profiling of Metabolites from Honey Bee Products
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Chemical Profiling of Metabolites from Honey Bee Products

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Food Metabolomics".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 2976

Special Issue Editors

Dr. Marina Kranjac

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Guest Editor
Faculty of Science, University of Split, Ruđera Boškovića 33, 21000 Split, Croatia
Interests: gas chromatography–mass spectrometry; chemical profiles and biomarkers of unifloral honeys; identification of potential markers of botanical origin; application of complementary extraction methodologies (HS-SPME; head-space solid-phase mixroextraction; USE; ultrasonic solvent extraction; SPE; solid-phase extraction); antioxidant activity
Special Issues, Collections and Topics in MDPI journals
Dr. Carlo I.G. Tuberoso

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Guest Editor
Department of Life and Environmental Sciences, Università degli studi di Cagliari, Cagliari, Italy
Interests: food chemistry and analysis; natural bioactive compounds; antioxidants; phenolic compounds; beehive products; analytical chemistry; validation of analytical methods; extraction techniques; liquid-chromatography; gas-chromatography; hyphenated methods; chemometrics and data analysis; agro-food quality control; by-product valorization
Special Issues, Collections and Topics in MDPI journals
Dr. Piotr Marek Kuś

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Guest Editor
Department of Pharmacognosy and Herbal Medicines, Faculty of Pharmacy, Wroclaw Medical University, ul. Borowska 211a, 50-556 Wrocław, Poland
Interests: pharmacognosy, phytochemistry, bee products, food chemistry, liquid-chromatography, gas-chromatography, mass spectrometry, chemometrics
Special Issues, Collections and Topics in MDPI journals
Dr. Saša Prđun

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Guest Editor
Faculty of Agriculture, University of Zagreb, Svetošimunska Cesta 25, 10000 Zagreb, Croatia
Interests: honey analytics; nectar flow plants; honey bee biology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Honey bee products such as honey, bee pollen, royal jelly and propolis are known for their nutritional and health-promoting properties and are rich in primary and secondary metabolites. Research on metabolites from honey bee products (BPs) can make an important contribution to the authenticity assessment, quality control, determination and traceability of the origin of honey bee products. The determination of chemical profiles and the identification of characteristic metabolites of different honey bee products can significantly contribute to their characterization and facilitate the detection of adulteration. In addition, chemical profiling can be an efficient strategy for the discovery of bioactive natural compounds, providing valuable insights and a better understanding of the biological activity of honey bee products characterized by a rich chemical composition. This Special Issue focuses on the determination of metabolites and their presence in different bee products and their possible biosynthetic/metabolic relationships. The objective of this Special Issue, entitled “Chemical Profiling of Metabolites from Honey Bee Products”, is to present the latest research findings on the metabolic profiling of honey bee products based on spectroscopic and chromatographic techniques such as high-resolution nuclear magnetic resonance (NMR) spectroscopy and gas (GC), liquid (LC), ultra-high-pressure liquid (UPLC) and high-performance liquid chromatography (HPLC). This includes the identification of marker compounds and bioactive compounds, data analysis (data mining/extraction, statistical analysis), the assessment of the bioactive potential of honey bee products and the effects of consumption on metabolic perturbations in humans as well as other characteristics and effects of bee products and their metabolites revealed by different approaches.

Dr. Marina Kranjac
Dr. Carlo I.G. Tuberoso
Dr. Piotr Marek Kuś
Dr. Saša Prđun
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • honey bee products
  • chemical profiles
  • biomarkers
  • authenticity assessment
  • bioactive compounds
  • bioactive potential
  • metabolic perturbations

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Published Papers (2 papers)

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Research

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12 pages, 1190 KiB  
Article
Detection of Sugar Syrups in Honey Using Untargeted Liquid Chromatography–Mass Spectrometry and Chemometrics
by Jule Hansen, Christof Kunert, Kurt-Peter Raezke and Stephan Seifert
Metabolites 2024, 14(11), 633; https://doi.org/10.3390/metabo14110633 - 16 Nov 2024
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Abstract
Background: Honey is one of the most adulterated foods worldwide, and several analytical methods have been developed over the last decade to detect syrup additions to honey. These include approaches based on stable isotopes and the specific detection of individual marker compounds [...] Read more.
Background: Honey is one of the most adulterated foods worldwide, and several analytical methods have been developed over the last decade to detect syrup additions to honey. These include approaches based on stable isotopes and the specific detection of individual marker compounds or foreign enzymes. Proton nuclear magnetic resonance (1H-NMR) spectroscopy is applied as a rapid and comprehensive screening method, which also enables the detection of quality parameters and the analysis of the geographical and botanical origin. However, especially for the detection of foreign sugars, 1H-NMR has insufficient sensitivity. Methods: Since untargeted liquid chromatography–mass spectrometry (LC-MS) is more sensitive, we used this approach for the detection of positive and negative ions in combination with a recently developed data processing workflow for routine laboratories based on bucketing and random forest for the detection of rice, beet and high-fructose corn syrup in honey. Results: We show that the distinction between pure and adulterated honey is possible for all three syrups, with classification accuracies ranging from 98 to 100%, while the accuracy of the syrup content estimation depends on the respective syrup. For rice and beet syrup, the deviations from the true proportion were in the single-digit percentage range, while for high-fructose corn syrup they were much higher, in some cases exceeding 20%. Conclusions: The approach presented here is very promising for the robust and sensitive detection of syrup in honey applied in routine laboratories. Full article
(This article belongs to the Special Issue Chemical Profiling of Metabolites from Honey Bee Products)
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Review

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27 pages, 5525 KiB  
Review
Chromatography-Based Metabolomics as a Tool in Bioorganic Research of Honey
by Marina Kranjac, Piotr Marek Kuś, Saša Prđun, Renata Odžak and Carlo Ignazio Giovanni Tuberoso
Metabolites 2024, 14(11), 606; https://doi.org/10.3390/metabo14110606 - 8 Nov 2024
Viewed by 1269
Abstract
This review presents the latest research on chromatography-based metabolomics for bioorganic research of honey, considering targeted, suspect, and untargeted metabolomics involving metabolite profiling and metabolite fingerprinting. These approaches give an insight into the metabolic diversity of different honey varieties and reveal different classes [...] Read more.
This review presents the latest research on chromatography-based metabolomics for bioorganic research of honey, considering targeted, suspect, and untargeted metabolomics involving metabolite profiling and metabolite fingerprinting. These approaches give an insight into the metabolic diversity of different honey varieties and reveal different classes of organic compounds in the metabolic profiles, among which, key metabolites such as biomarkers and bioactive compounds can be highlighted. Chromatography-based metabolomics strategies have significantly impacted different aspects of bioorganic research, including primary areas such as botanical origins, honey origin traceability, entomological origins, and honey maturity. Through the use of different tools for complex data analysis, these strategies contribute to the detection, assessment, and/or correlation of different honey parameters and attributes. Bioorganic research is mainly focused on phytochemicals and their transformation, but the chemical changes that can occur during the different stages of honey formation remain a challenge. Furthermore, the latest user- and environmentally friendly sample preparation methods and technologies as well as future perspectives and the role of chromatography-based metabolomic strategies in honey characterization are discussed. The objective of this review is to summarize the latest metabolomics strategies contributing to bioorganic research onf honey, with emphasis on the (i) metabolite analysis by gas and liquid chromatography techniques; (ii) key metabolites in the obtained metabolic profiles; (iii) formation and accumulation of biogenic volatile and non-volatile markers; (iv) sample preparation procedures; (v) data analysis, including software and databases; and (vi) conclusions and future perspectives. For the present review, the literature search strategy was based on the PRISMA guidelines and focused on studies published between 2019 and 2024. This review outlines the importance of metabolomics strategies for potential innovations in characterizing honey and unlocking its full bioorganic potential. Full article
(This article belongs to the Special Issue Chemical Profiling of Metabolites from Honey Bee Products)
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