Amino Acid Metabolism and Function in Human Diseases

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Cell Metabolism".

Deadline for manuscript submissions: closed (30 April 2025) | Viewed by 852

Special Issue Editors


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Guest Editor
Department of Clinical Biochemistry, Institute of Pediatrics, Jagiellonian University Medical College, Wielicka St. 265, 30-663 Krakow, Poland
Interests: metabolism of amino acids; fatty acids; bile acids; civilization diseases; obesity; gallstone disease; colorectal cancer

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Guest Editor
Department of Clinical Biochemistry, Institute of Pediatrics, Jagiellonian University Medical College, Wielicka St. 265, 30-663 Krakow, Poland
Interests: metabolic syndrome; pediatrics; surgery

Special Issue Information

Dear Colleagues,

Disturbances in amino acid biochemical pathways have been linked to many civilization diseases such as diabetes, obesity, liver disease, and heart disease, which are associated with changes in lifestyle, improper diet, and low physical activity. Early detection and proper action preventing the development of civilization diseases in children is of special importance. As more evidence concerning amino acid disturbances connected with civilization disease is published, gaining more knowledge on their profile in various biological fluids in children is meaningful. Although the biochemistry of amino acid metabolism is known, appropriate amino acid profile interpretation using adequate reference intervals in children is just as important as understanding the role of each individual amino acid in disease onset and progression.

In this Special Issue, we aim to provide new insights into amino acid metabolism in different human diseases linked to environmental changes, both children and adults. As more and more laboratories are technically ready to accurately and precisely measure amino acid profiles in biological fluids, looking at different amino acid profiles and using them as independent predictors of disease progression deserves in-depth study.

Dr. Jolanta Bugajska
Prof. Dr. Krystyna Sztefko
Guest Editors

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Keywords

  • free amino acids
  • civilization diseases
  • obesity
  • diabetes
  • liver disease
  • heart diseases
  • reference intervals

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Published Papers (1 paper)

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Review

14 pages, 3142 KiB  
Review
Metabolism of Tryptophan, Glutamine, and Asparagine in Cancer Immunotherapy—Synergism or Mechanism of Resistance?
by Kajetan Kiełbowski, Estera Bakinowska, Rafał Becht and Andrzej Pawlik
Metabolites 2025, 15(3), 144; https://doi.org/10.3390/metabo15030144 - 21 Feb 2025
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Abstract
Amino acids are crucial components of proteins, key molecules in cellular physiology and homeostasis. However, they are also involved in a variety of other mechanisms, such as energy homeostasis, nitrogen exchange, further synthesis of bioactive compounds, production of nucleotides, or activation of signaling [...] Read more.
Amino acids are crucial components of proteins, key molecules in cellular physiology and homeostasis. However, they are also involved in a variety of other mechanisms, such as energy homeostasis, nitrogen exchange, further synthesis of bioactive compounds, production of nucleotides, or activation of signaling pathways. Moreover, amino acids and their metabolites have immunoregulatory properties, significantly affecting the behavior of immune cells. Immunotherapy is one of the oncological treatment methods that improves cytotoxic properties of one’s own immune system. Thus, enzymes catalyzing amino acid metabolism, together with metabolites themselves, can affect immune antitumor properties and responses to immunotherapy. In this review, we will discuss the involvement of tryptophan, glutamine, and asparagine metabolism in the behavior of immune cells targeted by immunotherapy and summarize results of the most recent investigations on the impact of amino acid metabolites on immunotherapy. Full article
(This article belongs to the Special Issue Amino Acid Metabolism and Function in Human Diseases)
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