Nitrogen Nutrition and Metabolic Aging

Dear Colleagues,

"Nitrogen Nutrition and Metabolic Aging" has been a hot topic worldwide. Aging is a process associated with multiple-organ function decline and metabolic changes, characterized by enhanced susceptibility to a variety of diseases. Altered metabolome in the process of human aging can reveal gerontological markers and uncover underlying mechanisms that enhance susceptibility to aging-related diseases. Leading by protein, nucleic acid, and vitamin B groups, nitrogen composition in food plays a central role in human nutrition. In recent years, with the rapid development of food science and technology and nutrition research, the physiological functions of active food substances containing nitrogen, such as bioactive oligopeptides, dietary nucleotides, and their derivatives (e.g., nicotinamide mononucleotide), have been gradually revealed.

The identification and quantification of active compounds are of great value given that they reveal their functions. The development of omics technology and analytical chemistry has provided us with powerful tools to further understand nitrogen components, making it possible to further discover, analyze, and identify food composition and biomarkers, as well as to explain the mechanism between internal and external exposure in humans. We hope to attract good research on nitrogen nutrition from all over the world so that we can have a more comprehensive understanding of their effects on aging. We still do not understand the deep relationship between nitrogen nutrition and metabolic aging. Therefore, as the first step towards creating this research area, the latest progress in our understanding of “nitrogen nutrition” will be presented. We welcome manuscripts from the following subtopics:

• Identification and quantification of nitrogen substance in food, especially using omics;
• Demonstration of the molecular mechanisms of nitrogen substances (such as bioactive oligopeptides, exogenous nucleotides) exhibiting health or anti-aging functions in vivo and in vitro;
• The investigation of metabolism and bioactivities of nitrogen substances by using clinical trials;
• Effects of nitrogen substances on aging, chronic diseases, and mechanisms;
• Nitrogen substance-derived functional foods.

Dr. Meihong Xu
Guest Editor

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• bioactive peptides
• exogenous nucleotides
• nutrition
• life-course health
• hydrolyzed protein
• nitrogen
• oligopeptides