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Metabolites
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Advances in Ecotoxicology and Metabolism
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Advances in Ecotoxicology and Metabolism

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Environmental Metabolomics".

Deadline for manuscript submissions: closed (31 October 2024) | Viewed by 1324

Special Issue Editor

Dr. Chan Xiong

E-Mail Website
Guest Editor
1. Institute of Chemistry, University of Graz, Graz, Austria
2. Core Facility Mass Spectrometry, BOKU University, Muthgasse 11, 1190 Vienna, Austria
Interests: meabolism

Special Issue Information

Dear Colleagues,

Amidst escalating environmental concerns, understanding how various traditional and emerging environmental pollutants impact biota and, consequently, human health and environmental development is paramount. Leveraging mass spectrometry detection, this special issue delves into the intricate mechanisms by which pollutants influence biological systems. With a specific focus on metabolite changes resulting from the biological effects of individual pollutants or their combinations, the scope of this issue extends to the examination of environmental samples, biological entities and tissues, microbial specimens, and metabolites from specific biological locales, such as the intestine.

This special issue offers an opportunity for researchers to share the multifaceted realms of metallomics, heavy metal metabolism, ecotoxicology, and advanced analytical techniques such as HPLC-ICPMS and HRMS.

The primary focus of this special issue is to elucidate the intricate mechanisms governing the metabolism of heavy metals and other environmental pollutants within biological systems. By exploring the interplay between exposure, metabolism, and toxicity, we aim to uncover novel insights into the biochemical pathways underlying ecotoxicological responses.

The scope of this special issue encompasses a broad spectrum of research areas, ranging from the exploration of gut microbiota metabolites to the investigation of environmental metabolites and their impact on human health and ecosystem integrity. We welcome contributions that span experimental, theoretical, and computational approaches, offering diverse perspectives on the dynamics of metabolite transportation and distribution within biological matrices.

By elucidating these dynamics, we aim to advance our understanding of ecotoxicological processes and contribute to the development of evidence-based strategies for mitigating the adverse effects of environmental contaminants on global health and biodiversity. Join us in this collaborative endeavor to illuminate the complexities of ecotoxicology and metabolism and pave the way for a sustainable future.

Dr. Chan Xiong
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • environmental pollutants
  • mass spectrometry
  • biological systems
  • metallomics
  • heavy metal metabolism
  • biochemical pathways
  • gut microbiota metabolites
  • environmental metabolites
  • ecosystem integrity

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Published Papers (1 paper)

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Research

10 pages, 1912 KiB  
Article
Metabolomic Prediction of Cadmium Nephrotoxicity in the Snail Helix aspersa maxima
by Aude Devalckeneer, Marion Bouviez, Amandine Gautier and Jean-Marie Colet
Metabolites 2024, 14(8), 455; https://doi.org/10.3390/metabo14080455 - 17 Aug 2024
Viewed by 1054
Abstract
The decontamination of polluted soils is a major socioeconomic issue in many industrialized countries. In situ remediation approaches are nowadays preferred to ex situ techniques, but they require among others the use of bioindicators, which are sensitive to the progressive depollution on health [...] Read more.
The decontamination of polluted soils is a major socioeconomic issue in many industrialized countries. In situ remediation approaches are nowadays preferred to ex situ techniques, but they require among others the use of bioindicators, which are sensitive to the progressive depollution on health effects. Animal species have been mainly used so far to monitor aquatic and air pollution. Current research focuses on the development of living indicators of soil pollution. In this study, the garden snail Helix aspersa maxima was acutely exposed to cadmium, one major soil contaminant causing severe health effects, including nephrotoxicity. Kidney and hemolymph were sampled and analyzed by a 1H-NMR-based metabonomic approach. Shortly after Cd exposure, numerous metabolic changes occurred in the hemolymph and kidney extracts. Altogether, they were indicative of a switch in energy sources from the Krebs cycle towards b-oxidation and the utilization of stored galactogen polysaccharides. Then, the activation of antioxidant defenses in the renal cells was suggested by the alteration in some precursors of glutathione synthesis, such as glutamate, and by the release of the antioxidant anserin. Cell membrane damage was evidenced by the increased levels of some osmolytes, betaine and putrescine, as well as by a membrane repair mechanism involving choline. Finally, the development of metabolic acidosis was suggested by the elevation in 3-HMG in the hemolymph, and the more pronounced lysine levels were consistent with acute excretion troubles. Cd-induced renal damage was objectified by the increased level of riboflavin, a recognized biomarker of nephrotoxicity. Full article
(This article belongs to the Special Issue Advances in Ecotoxicology and Metabolism)
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