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The Emerging Role of Metabolomics in Epidemiological Studies of Atherosclerosis...
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The Emerging Role of Metabolomics in Epidemiological Studies of Atherosclerosis and Cardiovascular Disease

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Advances in Metabolomics".

Deadline for manuscript submissions: closed (20 July 2024) | Viewed by 3523

Special Issue Editors

Dr. Hao Peng

E-Mail Website
Guest Editor
Department of Epidemiology, School of Public Health, Suzhou Medical College of Soochow University, Suzhou 215123, China
Interests: cardiovascular disease; epidemiology; metabolic disease; metabolomics; epigenetics
Prof. Dr. Chenwei Pan

E-Mail Website
Guest Editor
School of Public Health, Medical College of Soochow University, Suzhou 215123, China
Interests: epidemiology; eye disease; metabolomics
Special Issues, Collections and Topics in MDPI journals
Dr. Changwei Li

E-Mail Website
Guest Editor
Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA
Interests: multi-omics study; GxE interactions; cardiovascular disease epidemiology; chronic kidney disease epidemiology

Special Issue Information

Dear Colleagues,

Cardiovascular disease (CVD) affects around two-thirds of the world’s population. A better understanding of its mechanisms and risk factors is of critical importance for the prevention and management of this debilitating disorder. Recently, a plethora of omics studies have emerged. These multi-omics studies have helped uncover many potential candidate biomarkers and risk factors for CVD and related vascular disorders. Studies deeply exploring these biomarkers are urgently needed for translational medicine.

This Special Issue aims to extensively highlight current knowledge about newly identified metabolic markers for CVD and vascular disorders, including basic, clinical, epidemiologic and genetic findings. Here, vascular disorders include heart disease (myocardial infarction, angina, heart failure), stroke, and peripheral vascular disease. Multi-omics studies, including genomics, epigenomics, transcriptomics, proteomics, metabolomics, and gut microbiome studies, are particularly welcome.

Potential topics include, but are not limited to, the following:

  • Metabolites involved in the pathogenesis of CVD and vascular disorders;
  • Novel proteins and related pathways involved in CVD and vascular disorders;
  • The identification of lifestyle behaviors and environmental factors that modify the risks of CVD and related disorders;
  • Novel findings linking early life experience to the development of CVD and vascular disorders in later life

Dr. Hao Peng
Prof. Dr. Chenwei Pan
Dr. Changwei Li
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiovascular disease
  • epidemiology
  • metabolic disease
  • metabolomics
  • multi-omics

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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16 pages, 2882 KiB  
Article
Metabolome Alterations Associated with Three-Month Sitting-Time Reduction Among Sedentary Postmenopausal Latinas with Cardiometabolic Disease Risk
by Jeffrey S. Patterson, Paniz Jasbi, Yan Jin, Haiwei Gu, Matthew A. Allison, Chase Reuter, Brinda K. Rana, Loki Natarajan and Dorothy D. Sears
Metabolites 2025, 15(2), 75; https://doi.org/10.3390/metabo15020075 - 26 Jan 2025
Viewed by 895
Abstract
Background: Incidence of cardiometabolic disease among U.S. Hispanics/Latinos is higher than in non-Hispanic Whites. Prolonged sitting duration is prevalent in older adults, and compounded with menopause, greatly increases cardiometabolic risk in postmenopausal women. Metabolomic analyses of interventions to reduce sitting are lacking and [...] Read more.
Background: Incidence of cardiometabolic disease among U.S. Hispanics/Latinos is higher than in non-Hispanic Whites. Prolonged sitting duration is prevalent in older adults, and compounded with menopause, greatly increases cardiometabolic risk in postmenopausal women. Metabolomic analyses of interventions to reduce sitting are lacking and mechanistic understanding of health-promoting behavior change in postmenopausal Latinas is needed. Methods: To address this knowledge gap, an exploratory analysis investigated the plasma metabolome impact of a 12-week increased standing intervention among sedentary postmenopausal Latinas with overweight or obesity. From a parent-randomized controlled trial, a subset of Best Responders (n = 43) was selected using parameters of highest mean change in sitting bout duration and total sitting time; baseline variable-Matched Controls (n = 43) were selected using random forest modeling. Targeted LC-MS/MS analysis of archived baseline and 12-week plasma samples was conducted. Metabolite change was determined using a covariate-controlled general linear model and multivariate testing was performed. A false discovery rate correction was applied to all analyses. Results: Best Responders significantly changed time sitting (−110.0 ± 11.0 min; −21%), standing (104.6 ± 10.1 min; 40%), and sitting in bouts >30 min (−102.3 ± 13.9 min; −35%) compared to Matched Controls (7.1 ± 9.8 min, −7.8 ± 9.0 min, and −4.6 ± 12.7 min, respectively; all p < 0.001). Twelve-week metabolite change was significantly different between the two groups for 24 metabolites (FDR < 0.05). These were primarily related to amino acid metabolism, improved blood flow, and ATP production. Enzyme enrichment analysis predicted significant changes regulating glutamate, histidine, phenylalanine, and mitochondrial short-chain fatty acid catabolism. Pathway analysis showed significant intervention effects on glutamate metabolism and phenylalanine, tyrosine, and tryptophan biosynthesis, potentially indicating reduced cardiometabolic disease risk. Conclusions: Replacing nearly two hours of daily sitting time with standing and reduced prolonged sitting bouts significantly improved metabolomic profiles associated with cardiometabolic risk among postmenopausal Latinas. Full article
(This article belongs to the Special Issue The Emerging Role of Metabolomics in Epidemiological Studies of Atherosclerosis and Cardiovascular Disease)
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16 pages, 4642 KiB  
Article
Sitting Interruption Modalities during Prolonged Sitting Acutely Improve Postprandial Metabolome in a Crossover Pilot Trial among Postmenopausal Women
by Jeffrey S. Patterson, Brinda K. Rana, Haiwei Gu and Dorothy D. Sears
Metabolites 2024, 14(9), 478; https://doi.org/10.3390/metabo14090478 - 30 Aug 2024
Cited by 2 | Viewed by 1604
Abstract
Older adults sit during most hours of the day; more than 30% are considered physically inactive. The accumulation of prolonged sitting time is an exercise-independent risk factor for aging-related conditions such as cardiometabolic disease and cancer. Archival plasma samples from a randomized controlled, [...] Read more.
Older adults sit during most hours of the day; more than 30% are considered physically inactive. The accumulation of prolonged sitting time is an exercise-independent risk factor for aging-related conditions such as cardiometabolic disease and cancer. Archival plasma samples from a randomized controlled, four-condition crossover study conducted in 10 postmenopausal women with overweight or obesity were analyzed. During 5-hour conditions completed on separate days, the trial tested three interruption modalities: two-minute stands each 20 min (STS), hourly ten-minute standing breaks (Stand), hourly two-minute walks (Walk), and a controlled sit. Fasting baseline and 5-hour end point (2 h postprandial) samples were used for targeted metabolomic profiling. Condition-associated metabolome changes were compared using paired t-tests. STS eliminated the postprandial elevation of amino acid metabolites that was observed in the control. A norvaline derivative shown to have anti-hypertensive and -hyperglycemic effects was significantly increased during Stand and STS. Post-hoc testing identified 19 significantly different metabolites across the interventions. Tight metabolite clustering by condition was driven by amino acid, vasoactive, and sugar metabolites, as demonstrated by partial least squares-discriminant analyses. This exploratory study suggests that brief, low-intensity modalities of interrupting prolonged sitting can acutely elucidate beneficial cardiometabolic changes in postmenopausal women with cardiometabolic risk. Full article
(This article belongs to the Special Issue The Emerging Role of Metabolomics in Epidemiological Studies of Atherosclerosis and Cardiovascular Disease)
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