Interaction of Proteins with Biomembrane

Dear Colleagues,

The plasma and intracellular membranes are characterized by differing lipid compositions that enable proteins to localize to distinct subcellular compartments. A large number of proteins are known to interact with subcellular and cell membranes. Lipid–protein interactions determine protein conformations and protein–protein interactions, both of which, in turn, precisely regulate the localization and activation of molecular complexes at the respective membranes. Furthermore, membrane-bound proteins can control lipid/protein lateral diffusion and clustering, membrane fluidity, and membrane tension, which can induce intracellular signaling. These signaling pathways play crucial roles in various cellular processes such as cell migration, morphogenesis, membrane trafficking, and signal transduction. However, due to the complexity of the abundant protein–protein interactions within a cell, the exact molecular mechanisms by which proteins interact with lipids at the membrane interface remain unclear.

The aim of this Special Issue is to discuss the recent advances in lipid–protein interactions from various perspectives, such as cell biology, biochemistry, and biophysics. These studies will lead to elucidation of the underlying mechanisms by which membranes regulate the physiological functions of proteins and provide new insights into the fundamental principles of lipid–protein interactions.

Dr. Yosuke Senju
Prof. Dr. Shiro Suetsugu
Guest Editors

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