Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
6.1
3.3
Journals
Membranes
Special Issues
Characterization and Roles of Membrane Lipids
share announcement

Characterization and Roles of Membrane Lipids

A special issue of Membranes (ISSN 2077-0375). This special issue belongs to the section "Biological Membrane Functions".

Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 11437

Special Issue Editors

Dr. Chuan-Ho Tang

E-Mail Website
Guest Editor
National Museum of Marine Biology and Aquarium, 2 Houwan Rd., Checheng, Pingtung 944, Taiwan
Interests: membrane biology; lipidomics; coral ecotoxicology; mass spectrometry-based analysis
Prof. Dr. Ching-Yu Lin

E-Mail Website
Guest Editor
Institute of Environmental and Occupational Health Sciences, National Taiwan University, Taipei, Taiwan
Interests: toxicology; metabolomics; proteomics; analytical chemistry
Dr. Sheng-Han Lee

E-Mail Website
Guest Editor
Institute of Environmental and Occupational Health Sciences, College of Public Health, National Taiwan University, Taipei, Taiwan
Interests: lipidomics; metabolomics; toxicology; nanotoxicology; pm2.5

Special Issue Information

Dear Colleagues,

Membrane lipids are thought to play a role in various biotic and abiotic processes.  Because of the diversity of their molecular structure, membrane lipids present multiple physicochemical properties and, by assembling in complexes, they acquire collective behaviors under various physical and chemical conditions.  Understanding how lipid diversity is produced and for what purposes is the subject of extensive investigation.  Especially, in biological systems, lipids’ physiological maintenance and its (mis-)regulation as well as various diseases related to lipids are extensively explored using lipidomics and other combinatory approaches.  Therefore, the mechanisms whereby membrane lipids exert their effects or functions are being clarified.  The molecular principles of membrane lipids are applied in various investigation fields, such as tissue engineering, for therapeutic purposes.  This Special Issue will present research studies on lipids, investigating aspects related to biology, medicine, nutriology, pharmacology, toxicology, environmental science, methodology, analytical chemistry, and corresponding applications.  Authors are invited to submit their latest original research papers or review articles.

Dr. Chuan-Ho Tang
Prof. Dr. Ching-Yu Lin
Dr. Sheng-Han Lee
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Membranes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Lipid profiling
  • Lipid analysis
  • Lipid metabolism
  • Structure–function relationship
  • Lipid effects
  • Lipid assembly
  • Lipid interaction
  • Lipid behavior
  • Membrane dynamics
  • Interfacial reaction

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

18 pages, 10251 KiB  
Article
Phosphatidylglycerol Supplementation Alters Mitochondrial Morphology and Cardiolipin Composition
by I Chu, Ying-Chih Chen, Ruo-Yun Lai, Jui-Fen Chan, Ya-Hui Lee, Maria Balazova and Yuan-Hao Howard Hsu
Membranes 2022, 12(4), 383; https://doi.org/10.3390/membranes12040383 - 31 Mar 2022
Cited by 3 | Viewed by 3151
Abstract
The pathogenic variant of the TAZ gene is directly associated with Barth syndrome. Because tafazzin in the mitochondria is responsible for cardiolipin (CL) remodeling, all molecules related to the metabolism of CL can affect or be affected by TAZ mutation. In this study, [...] Read more.
The pathogenic variant of the TAZ gene is directly associated with Barth syndrome. Because tafazzin in the mitochondria is responsible for cardiolipin (CL) remodeling, all molecules related to the metabolism of CL can affect or be affected by TAZ mutation. In this study, we intend to recover the distortion of the mitochondrial lipid composition, especially CL, for Barth syndrome treatment. The genetically edited TAZ knockout HAP1 cells were demonstrated to be a suitable cellular model, where CL desaturation occurred and monolyso-CL (MLCL) was accumulated. From the species analysis by mass spectrometry, phosphatidylethanolamine showed changed species content after TAZ knockout. TAZ knockout also caused genetic down-regulation of PGS gene and up-regulation of PNPLA8 gene, which may decrease the biosynthesis of CLs and increase the hydrolysis product MLCL. Supplemented phosphatidylglycerol(18:1)2 (PG(18:1)2) was successfully biosynthesized to mature symmetrical CL and drastically decrease the concentration of MLCL to recover the morphology of mitochondria and the cristae shape of inner mitochondria. Newly synthesized mature CL may induce the down-regulation of PLA2G6 and PNPLA8 genes to potentially decrease MLCL production. The excess supplemented PG was further metabolized into phosphatidylcholine and phosphatidylethanolamine. Full article
(This article belongs to the Special Issue Characterization and Roles of Membrane Lipids)
►▼ Show Figures

Figure 1

14 pages, 13233 KiB  
Article
Silicon Nitride-Based Micro-Apertures Coated with Parylene for the Investigation of Pore Proteins Fused in Free-Standing Lipid Bilayers
by Tanzir Ahmed, Jayesh Arun Bafna, Roland Hemmler, Karsten Gall, Richard Wagner, Mathias Winterhalter, Michael J. Vellekoop and Sander van den Driesche
Membranes 2022, 12(3), 309; https://doi.org/10.3390/membranes12030309 - 9 Mar 2022
Cited by 3 | Viewed by 2861
Abstract
In this work, we present a microsystem setup for performing sensitive biological membrane translocation measurements. Thin free-standing synthetic bilayer lipid membranes (BLM) were constructed in microfabricated silicon nitride apertures (<100 µm in diameter), conformal coated with Parylene (Parylene-C or Parylene-AF4). Within these BLMs, [...] Read more.
In this work, we present a microsystem setup for performing sensitive biological membrane translocation measurements. Thin free-standing synthetic bilayer lipid membranes (BLM) were constructed in microfabricated silicon nitride apertures (<100 µm in diameter), conformal coated with Parylene (Parylene-C or Parylene-AF4). Within these BLMs, electrophysiological measurements were conducted to monitor the behavior of different pore proteins. Two approaches to integrate pore-forming proteins into the membrane were applied: direct reconstitution and reconstitution via outer membrane vesicles (OMVs) released from Gram-negative bacteria. The advantage of utilizing OMVs is that the pore proteins remain in their native lipid and lipopolysaccharide (LPS) environment, representing a more natural state compared to the usage of fused purified pore proteins. Multiple aperture chips can be easily assembled in the 3d-printed holder to conduct parallel membrane transport investigations. Moreover, well defined microfabricated apertures are achievable with very high reproducibility. The presented microsystem allows the investigation of fast gating events (down to 1 ms), pore blocking by an antibiotic, and gating events of small pores (amplitude of approx. 3 pA). Full article
(This article belongs to the Special Issue Characterization and Roles of Membrane Lipids)
►▼ Show Figures

Figure 1

Review

Jump to: Research

15 pages, 769 KiB  
Review
Characterization and Roles of Membrane Lipids in Fatty Liver Disease
by Morgan Welch, Cassandra Secunda, Nabin Ghimire, Isabel Martinez, Amber Mathus, Urja Patel, Sarayu Bhogoju, Mashael Al-Mutairi, Kisuk Min and Ahmed Lawan
Membranes 2022, 12(4), 410; https://doi.org/10.3390/membranes12040410 - 9 Apr 2022
Cited by 9 | Viewed by 4467
Abstract
Obesity has reached global epidemic proportions and it affects the development of insulin resistance, type 2 diabetes, fatty liver disease and other metabolic diseases. Membrane lipids are important structural and signaling components of the cell membrane. Recent studies highlight their importance in lipid [...] Read more.
Obesity has reached global epidemic proportions and it affects the development of insulin resistance, type 2 diabetes, fatty liver disease and other metabolic diseases. Membrane lipids are important structural and signaling components of the cell membrane. Recent studies highlight their importance in lipid homeostasis and are implicated in the pathogenesis of fatty liver disease. Here, we discuss the numerous membrane lipid species and their metabolites including, phospholipids, sphingolipids and cholesterol, and how dysregulation of their composition and physiology contribute to the development of fatty liver disease. The development of new genetic and pharmacological mouse models has shed light on the role of lipid species on various mechanisms/pathways; these lipids impact many aspects of the pathophysiology of fatty liver disease and could potentially be targeted for the treatment of fatty liver disease. Full article
(This article belongs to the Special Issue Characterization and Roles of Membrane Lipids)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop