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Medicina
Special Issues
Recent Advances in Digestive Endoscopy
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Recent Advances in Digestive Endoscopy

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Gastroenterology & Hepatology".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 649

Special Issue Editors

Dr. Marco Spadaccini

E-Mail Website
Guest Editor
Digestive Endoscopy Unit, Department of Gastroenterology, Humanitas Clinical and Research Center, IRCCS, Rozzano, Milan, Italy
Interests: pancreatobiliary; advanced endoscopy; endoscopic ultrasound; endoscopic retrograde cholangiopancreatography; artificial intelligence; interventional EUS
Special Issues, Collections and Topics in MDPI journals
Dr. Alessandro Fugazza

E-Mail Website
Guest Editor
Digestive Endoscopy Unit, Department of Gastroenterology, Humanitas Clinical and Research Center, IRCCS, Rozzano, Milan, Italy
Interests: pancreatobiliary; advanced endoscopy; endoscopic ultrasound; endoscopic retrograde cholangiopancreatography; artificial intelligence; interventional EUS
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, clinical luminal and biliopancreatic endoscopy applications have been increasingly integrated into routine medical practice. The repertoire of endoscopists is expanding, with procedures becoming more complex and interventional, allowing for the minimally invasive management of a wider range of benign and malignant conditions. Notably, the introduction of artificial intelligence is transforming diagnostic endoscopy, while advancements in resection techniques and interventional endoscopic ultrasound (EUS) are significantly broadening the scope and indications of endoscopic procedures.

Recognizing the complexity and significant implications of these developments in clinical practice and public health, Medicina is launching a Special Issue titled “Recent Advances in Digestive Endoscopy”. Our aim in publishing this Special Issue is to compile accurate and innovative scientific information on various aspects of endoscopic management in both benign and malignant conditions.

We invite the submission of narrative and systematic reviews and original manuscripts.

Dr. Marco Spadaccini
Dr. Alessandro Fugazza
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • digestive endoscopy
  • cholangiopancreatography
  • advanced endoscopy

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Published Papers (1 paper)

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Research

13 pages, 934 KB  
Article
Bile Leak: Is There Optimal Timing for Endoscopy?
by Theodoros A. Voulgaris, Ioannis S. Papanikolaou, Dimitrios I. Ziogas, George Tribonias, Aliki Stamou, Aspasia Louta, Konstantinos Iliakopoulos, Ioannis A. Vezakis, Andreas Polydorou and Antonios Vezakis
Medicina 2025, 61(12), 2108; https://doi.org/10.3390/medicina61122108 - 27 Nov 2025
Viewed by 371
Abstract
Background and Objectives: Bile leak is a common complication after hepatopancreatobiliary surgery, requiring timely management to prevent life-threatening outcomes. Endoscopic retrograde cholangiopancreatography (ERCP) is essential in treatment, but large data concerning optimal timing and technique selection are unavailable. This study evaluates whether [...] Read more.
Background and Objectives: Bile leak is a common complication after hepatopancreatobiliary surgery, requiring timely management to prevent life-threatening outcomes. Endoscopic retrograde cholangiopancreatography (ERCP) is essential in treatment, but large data concerning optimal timing and technique selection are unavailable. This study evaluates whether the timing of ERCP influences healing and if different bile duct injuries affect outcomes. Materials and Methods: Data from a prospectively maintained database over 25 years (2001–2025) included 176 patients (M/F: 91/85, mean age 62) undergoing ERCP for bile leaks. Results: Most leaks followed cholecystectomy (n = 143, 81.5%). The median time from leak to ERCP was 7 days. Ten patients (5.7%) had complete common bile duct (CBD) transection—considered major leaks—requiring surgery. Among the 166 minor leaks, the cystic duct stump (40.1%) was the most common injury site, followed by the CBD (24.1%) and the gallbladder bed (15.4%). Healing occurred in 90.6%. Stent placement improved healing rates (93.9% vs. 75.9%, p = 0.007), with no difference between pig-tail and (Amsterdam) straight plastic stents (90% vs. 96%, p = 0.267). Retained CBD stones or CBD strictures did not affect outcomes. Leaks from the cystic duct stump had a 96.9% resolution rate, whereas gallbladder bed leaks healed in 88%. The median healing time was 2 days, unaffected by stent placement or ES alone (p = 0.842), but later ERCP correlated with longer healing (RR: 0.362, p < 0.001). Following a right aberrant bile leak, the time for healing was longer than in leaks from other sites. Conclusions: ERCP with stenting remains the first-line approach for minor bile leaks. Early ERCP accelerates healing, emphasizing the importance of prompt intervention. Full article
(This article belongs to the Special Issue Recent Advances in Digestive Endoscopy)
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